Nanoantibiotic particles for shape and size recognition of pathogens

Borovicka, Josef; Paunov, Vesselin; Stoyanov, Simeon D.

Abstract

We have developed a novel class of colloidal particles capable of shape and size recognition as well as specific binding to the target cells. These colloid particles were fabricated using a nanoimprinting technology which yields inorganic imprints of the chosen target microorganisms. The products of the templating process are partially fragmented inorganic shells which can selectively bind to their biological counterparts, therefore impairing microbial cell growth, replication and infection. We have named this class of particles, which are capable of selectively recognizing bacterial shape and size, “nanoantibiotics”, which can be further functionalized to kill the target cells. The selective binding is driven by the increased area of contact upon recognition of the cell shape and size between the cells and their matching inorganic shell fragments. Here, we demonstrate the cell recognition and binding action of such particles using two different microbial test organisms.

Citation

Borovicka, J., Paunov, V., & Stoyanov, S. D. (2013). Nanoantibiotic particles for shape and size recognition of pathogens. MRS Online Proceedings Library, 1498, 127 - 132. https://doi.org/10.1557/opl.2013.14

• Journal Article Type: Article
• Online Publication Date: Jan 14, 2013
• Publication Date: Dec 31, 2013
• Deposit Date: Jun 14, 2019
• Publicly Available Date: Jun 17, 2019
• Journal: Materials Research Society Symposium Proceedings
• Print ISSN: 0272-9172
• Publisher: Cambridge University Press
• Peer Reviewed: Peer Reviewed
• Volume: 1498
• Pages: 127 - 132
• DOI: https://doi.org/10.1557/opl.2013.14
• Keywords: colloid antibody, shape recognition, photothermal action, yeast, B. subtilis
• Public URL: https://hull-repository.worktribe.com/output/432552
• Publisher URL: https://www.cambridge.org/core/journals/mrs-online-proceedings-library-archive/article/nanoantibiotic-particles-for-shape-and-size-recognition-of-pathogens/124184B17577171F1AF1315E3BBD1E6A
• Contract Date: Jun 14, 2019