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Heat shock proteins in vascular disease - a review

Mehta, T.A.; Greenman, J.; Ettelaie, C.; Venkatasubramaniam, A.; Chetter, I.C.; McCollum, P.T.


T.A. Mehta

C. Ettelaie

A. Venkatasubramaniam

I.C. Chetter

P.T. McCollum


There is growing evidence that heat shock proteins (HSPs), a family of stress-inducible proteins may be involved in the pathogenesis of atherosclerotic vascular diseases. Here, we systematically review the evidence behind this notion.

A detailed literature search and extensive bibliographic review of literature relating to HSPs and atherosclerotic vascular disease.

Atherosclerotic vascular disease is classified into four main areas of presentation: carotid, coronary, aortic and peripheral vascular disease, for consideration in this review. In each of these vascular diseases, the evidence linking HSPs and atherosclerosis is outlined in a systematic manner. Current evidence suggests that components of the immune system may be involved in the pathogenesis of atherosclerosis, with HSPs acting as auto-antigens in the immune response. HSPs are detected in atherosclerotic lesions and antibodies to HSPs are increased in patients with vascular disease; the rise often correlating with the severity of atherosclerosis. The levels of anti-HSP antibodies have been shown to be independent predictors of risk and have prognostic value.

There is a strong link between heat shock protein expression and the principal manifestations of atherosclerotic vascular diseases. A better understanding of this involvement could lead to the development of new and improved treatment strategies.

Journal Article Type Article
Publication Date 2005-04
Journal European Journal of Vascular and Endovascular Surgery
Print ISSN 1078-5884
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 29
Issue 4
Pages 395-402
APA6 Citation Mehta, T., Greenman, J., Ettelaie, C., Venkatasubramaniam, A., Chetter, I., & McCollum, P. (2005). Heat shock proteins in vascular disease - a review. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 29(4), 395-402.
Keywords Surgery; Cardiology and Cardiovascular Medicine