Allogeneic versus autologous blood during abdominal aortic aneurysm surgery

Spark, J.I.; Chetter, I.C.; Kester, R.C.; Scott, D.J.A.

Abstract

Objectives: To determine if cell-salvaged autologous blood can serve as an alternative to homologous blood, and to examine the incidence of infected complications and length of postoperative stay. Design: A prospective randomised study comprising autologous and homologous blood transfections in patients undergoing elective infrarenal abdominal aortic surgery. Methods: Fifty patients undergoing AAA surgery were prospectively randomised to homologous blood (n = 27), or autologous blood transfusion (n = 23), using a cell salvage autotransfusion device. Results: The haemoglobin at the time of hospital discharge was similar for both groups (11.0 vs. 10.8 g/dl) with no difference in perioperative mortality. The length of stay was reduced in those patients who received autologous blood (9 days vs. 12 days, p < 0.05 Mann-Whitney U test). There were four infected cases in the autologous group and 12 in the homologous group (p = n.s., Fisher's exact probability test). However, patients who received 3-4 units of homologous blood had an increased risk of infection compared to those who received a similar amount of autologous blood (50% vs. 0%). Conclusions: Cell salvage autologous blood can safely replace, or at least decrease, exposure to homologous blood transfusion, with a reduction in the mean hospital stay.

Citation

Spark, J., Chetter, I., Kester, R., & Scott, D. (1997). Allogeneic versus autologous blood during abdominal aortic aneurysm surgery. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 14(6), 482-486. https://doi.org/10.1016/s1078-5884%2897%2980128-1

• Journal Article Type: Article
• Acceptance Date: Dec 1, 1997
• Publication Date: 1997-12
• Print ISSN: 1078-5884
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 14
• Issue: 6
• Pages: 482-486
• DOI: https://doi.org/10.1016/s1078-5884%2897%2980128-1
• Keywords: Surgery; Cardiology and Cardiovascular Medicine
• Public URL: https://hull-repository.worktribe.com/output/432654
• Publisher URL: http://www.ejves.com/article/S1078-5884(97)80128-1/abstract