Mutation of the Arabidopsis LON2 peroxisomal protease enhances pexophagy

Bartel, Bonnie; Farmer, Lisa M.; Rinaldi, Mauro A.; Young, Pierce G.; Danan, Charles H.; Burkhart, Sarah E.

Abstract

Peroxisomes are critical organelles housing various, often oxidative, reactions. Pexophagy, the process by which peroxisomes are selectively targeted for destruction via autophagy, is characterized in yeast and mammals but had not been reported in plants. In this article, we describe how the peroxisome-related aberrations of a mutant defective in the LON2 peroxisomal protease are suppressed when autophagy is prevented by mutating any of several key autophagy-related (ATG) genes. Our results reveal that plant peroxisomes can be degraded by selective autophagy and suggest that pexophagy is accelerated when the LON2 protease is disabled.

Citation

Bartel, B., Farmer, L. M., Rinaldi, M. A., Young, P. G., Danan, C. H., & Burkhart, S. E. (2014). Mutation of the Arabidopsis LON2 peroxisomal protease enhances pexophagy. Autophagy, 10(3), 518-519. https://doi.org/10.4161/auto.27565

• Journal Article Type: Article
• Acceptance Date: Dec 17, 2013
• Online Publication Date: Jan 9, 2014
• Publication Date: Jan 1, 2014
• Deposit Date: Aug 12, 2023
• Journal: Autophagy
• Print ISSN: 1554-8627
• Electronic ISSN: 1554-8635
• Publisher: Taylor and Francis Group
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 3
• Pages: 518-519
• DOI: https://doi.org/10.4161/auto.27565
• Keywords: Arabidopsis thaliana; Autophagy; Peroxisome remodeling; Peroxisomal protease; Pexophagy
• Public URL: https://hull-repository.worktribe.com/output/4355476