DNA methylation changes in CD4+ T cells isolated from multiple sclerosis patients on dimethyl fumarate

Maltby, Vicki E.; Lea, Rodney A.; Ribbons, Karen A.; Sanders, Katherine A.; Kennedy, Daniel; Min, Myintzu; Scott, Rodney J.; Lechner-Scott, Jeannette

Abstract

Background: Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood. Objective: To investigate the effects of dimethyl fumarate on DNA methylation in the CD4+ T cells of multiple sclerosis patients. Methods: We performed Illumina EPIC arrays to investigate the DNA methylation profiles of CD4+ T cells derived from multiple sclerosis patients before and after dimethyl fumarate treatment. Results: Treatment with dimethyl fumarate resulted in 97% of differentially methylated positions showing hypermethylation. Four genes, SNORD1A, SHTN1, MZB1 and TNF had a differentially methylated region located within the transcriptional start site. Conclusion: This study investigates the effect of dimethyl fumarate on DNA methylation in multiple sclerosis patients.

Citation

Maltby, V. E., Lea, R. A., Ribbons, K. A., Sanders, K. A., Kennedy, D., Min, M., Scott, R. J., & Lechner-Scott, J. (2018). DNA methylation changes in CD4+ T cells isolated from multiple sclerosis patients on dimethyl fumarate. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 4(3), https://doi.org/10.1177/2055217318787826

• Journal Article Type: Article
• Acceptance Date: May 24, 2018
• Online Publication Date: Jul 17, 2018
• Publication Date: Jul 1, 2018
• Deposit Date: Aug 23, 2023
• Publicly Available Date: Sep 27, 2023
• Journal: Multiple Sclerosis Journal - Experimental, Translational and Clinical
• Electronic ISSN: 2055-2173
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 3
• DOI: https://doi.org/10.1177/2055217318787826
• Public URL: https://hull-repository.worktribe.com/output/4366555
• Publisher URL: https://journals.sagepub.com/doi/10.1177/2055217318787826