Annie S. Anderson
Cancer prevention through weight control—where are we in 2020?
Anderson, Annie S.; Renehan, Andrew G.; Saxton, John M.; Bell, Joshua; Cade, Janet; Cross, Amanda J.; King, Angela; Riboli, Elio; Sniehotta, Falko; Treweek, Shaun; Martin, Richard M.
Authors
Andrew G. Renehan
Professor John Saxton John.Saxton@hull.ac.uk
Professor in Clinical Exercise Physiology and Head of the School of Sport, Exercise & Rehabilitation Sciences
Joshua Bell
Janet Cade
Amanda J. Cross
Angela King
Elio Riboli
Falko Sniehotta
Shaun Treweek
Richard M. Martin
Abstract
Growing data from epidemiological studies highlight the association between excess body fat and cancer incidence, but good indicative evidence demonstrates that intentional weight loss, as well as increasing physical activity, offers much promise as a cost-effective approach for reducing the cancer burden. However, clear gaps remain in our understanding of how changes in body fat or levels of physical activity are mechanistically linked to cancer, and the magnitude of their impact on cancer risk. It is important to investigate the causal link between programmes that successfully achieve short-term modest weight loss followed by weight-loss maintenance and cancer incidence. The longer-term impact of weight loss and duration of overweight and obesity on risk reduction also need to be fully considered in trial design. These gaps in knowledge need to be urgently addressed to expedite the development and implementation of future cancer-control strategies. Comprehensive approaches to trial design, Mendelian randomisation studies and data-linkage opportunities offer real possibilities to tackle current research gaps. In this paper, we set out the case for why non-pharmacological weight-management trials are urgently needed to support cancer-risk reduction and help control the growing global burden of cancer.
Citation
Anderson, A. S., Renehan, A. G., Saxton, J. M., Bell, J., Cade, J., Cross, A. J., King, A., Riboli, E., Sniehotta, F., Treweek, S., & Martin, R. M. (2021). Cancer prevention through weight control—where are we in 2020?. The British Journal of Cancer, 124(6), 1049-1056. https://doi.org/10.1038/s41416-020-01154-3
| Journal Article Type | Review |
|---|---|
| Acceptance Date | Oct 22, 2020 |
| Online Publication Date | Nov 25, 2020 |
| Publication Date | Mar 16, 2021 |
| Deposit Date | Aug 30, 2023 |
| Publicly Available Date | Sep 8, 2023 |
| Journal | British Journal of Cancer |
| Print ISSN | 0007-0920 |
| Electronic ISSN | 1532-1827 |
| Publisher | Nature Publishing Group |
| Peer Reviewed | Peer Reviewed |
| Volume | 124 |
| Issue | 6 |
| Pages | 1049-1056 |
| DOI | https://doi.org/10.1038/s41416-020-01154-3 |
| Keywords | Cancer prevention; Lifestyle modification; Public health |
| Public URL | https://hull-repository.worktribe.com/output/4372120 |
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© Cancer Research UK 2020.
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