Supported progressive resistance exercise training to counter the adverse side effects of robot-assisted radical prostatectomy: a randomised controlled trial

Ashton, Ruth E.; Aning, Jonathan J.; Tew, Garry A.; Robson, Wendy A.; Saxton, John M.

Abstract

Purpose: To investigate the effects of a supported home-based progressive resistance exercise training (RET) programme on indices of cardiovascular health, muscular strength and health-related quality of life (HR-QoL) in prostate cancer (PCa) patients after treatment with robot-assisted radical prostatectomy (RARP). Methods: This study was a single-site, two-arm randomised controlled trial, with 40 participants randomised to either the intervention or control group over a 10-month period. In addition to receiving usual care, the intervention group completed three weekly RET sessions using resistance bands for 6 months. Participants performed 3 sets of 12–15 repetitions for each exercise, targeting each major muscle group. The control group received usual care only. Brachial artery flow-mediated dilatation (FMD) was the primary outcome and assessed at baseline, 3 and 6 months. Secondary outcomes included body weight, body fat, aerobic fitness, strength and blood-borne biomarkers associated with cardiometabolic risk. Results: There was no significant difference between the groups in FMD at 3 or 6 months. However, there were improvements in aerobic exercise capacity (P < 0.01) and upper- (P < 0.01) and lower-limb (P = 0.01) strength in favour of the RET group at 6 months, accompanied by greater weight loss (P = 0.04) and a reduction in body fat (P = 0.02). Improvements in HRQoL were evident in the RET group at 3 and 6 months via the PCa-specific component of the FACT-P questionnaire (both P < 0.01). Five adverse events and one serious adverse event were reported throughout the trial duration. Conclusion: This study demonstrates that home-based RET is an effective and safe mode of exercise that elicits beneficial effects on aerobic exercise capacity, muscular strength and HR-QoL in men who have undergone RARP. Trial registration: ISRCTN10490647.

Citation

Ashton, R. E., Aning, J. J., Tew, G. A., Robson, W. A., & Saxton, J. M. (2021). Supported progressive resistance exercise training to counter the adverse side effects of robot-assisted radical prostatectomy: a randomised controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(8), 4595-4605. https://doi.org/10.1007/s00520-021-06002-5

• Journal Article Type: Article
• Acceptance Date: Jan 13, 2021
• Online Publication Date: Jan 23, 2021
• Publication Date: Aug 1, 2021
• Deposit Date: Aug 30, 2023
• Publicly Available Date: Sep 1, 2023
• Journal: Supportive Care in Cancer
• Print ISSN: 0941-4355
• Electronic ISSN: 1433-7339
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Issue: 8
• Pages: 4595-4605
• DOI: https://doi.org/10.1007/s00520-021-06002-5
• Keywords: Prostate cancer; Resistance exercise; Robot-assisted radical prostatectomy; Cardiometabolic
• Public URL: https://hull-repository.worktribe.com/output/4372154