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Templated mineralization by charge-modified cowpea mosaic virus

Aljabali, Alaa A A; Evans, David J.

Authors

Alaa A A Aljabali

David J. Evans

Abstract

Templated mineralization of virus particles provides routes to narrowly dispersed nanoparticles that are not readily prepared by other means. The templated mineralization of metal or metal oxide on the external surface of wild-type cowpea mosaic virus (CPMV), a plant virus, is facilitated by increasing the external surface negative charge. This is achieved by the chemical modification of surface lysine groups by succinic anhydride. Hence, for example, treatment of charge-modified CPMV succinamate with a 1:2 mixture of iron(II) and iron(III) salts, followed by raising the pH to 10.2, led to the formation of narrowly dispersed, CPMV-templated, magnetite (Fe3O4) nanoparticles.

Book Type Book Chapter
Publication Date Jan 1, 2014
Journal Virus hybrids as nanomaterials
Print ISSN 1064-3745
Electronic ISSN 1940-6029
Publisher Humana Press
Peer Reviewed Not Peer Reviewed
Volume 1108
Pages 89-95
Book Title Methods in Molecular Biology; Virus Hybrids as Nanomaterials
ISBN 9781627037501; 9781627037518
DOI https://doi.org/10.1007/978-1-62703-751-8_6
Keywords Nanoparticles, Iron oxide, Magnetite, Cowpea mosaic virus, Templated mineralization
Publisher URL The final publication is available at Springer via http://dx.doi.org/10.1007/978-1-62703-751-8_6
Copyright Statement © 2016 the authors

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