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Embryo metabolism : what does it really mean?

Sturmey, Roger; Lewis, Niamh

Authors

Niamh Lewis



Abstract

The study of early embryo metabolism has fascinated researchers in the field for nearly a century. Herein, we give a brief account of the general features of embryo metabolism and some consideration of the research performed to reach such conclusions. It is becoming increasingly obvious that metabolism informs many fate decisions and outcomes beyond ATP generation, such as DNA methylation, Reactive Oxygen Species generation and cell signaling. We discuss the reasons for studying metabolism in the face of our current knowledge of the effect that the culture environment on the developing embryo and the downstream effects that can cause. The study of in vitro embryo metabolism can also give us insight into developmental perturbations in vivo. The strengths and limitations of the methods we use to study metabolism are reviewed with reference to species-specific fundamental biology and plasticity and we discuss what the future holds for metabolic studies and the unanswered questions that remain.

Citation

Sturmey, R., & Lewis, N. (2015). Embryo metabolism : what does it really mean?. Animal reproduction / Colegio Brasileiro de Reproducao Animal, 12(3), 521-528

Journal Article Type Article
Acceptance Date Jul 23, 2015
Publication Date 2015-07
Deposit Date Aug 18, 2016
Publicly Available Date Mar 29, 2024
Journal Animal reproduction
Print ISSN 1806-9614
Electronic ISSN 1984-3143
Peer Reviewed Peer Reviewed
Volume 12
Issue 3
Pages 521-528
Keywords ATP generation, Method evaluation, Preimplantation development
Public URL https://hull-repository.worktribe.com/output/442245
Publisher URL https://www.animal-reproduction.org/article/5b5a6033f7783717068b4616
Additional Information This is the authors' accepted manuscript of an article published in Animal reproduction, 2015, v.12 issue 3.

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