Lori B. Chibnik
Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium
Chibnik, Lori B.; Wolters, Frank J.; Bäckman, Kristoffer; Beiser, Alexa; Berr, Claudine; Bis, Joshua C.; Boerwinkle, Eric; Bos, Daniel; Brayne, Carol; Dartigues, Jean Francois; Darweesh, Sirwan K.L.; Debette, Stephanie; Davis-Plourde, Kendra L.; Dufouil, Carole; Fornage, Myriam; Grasset, Leslie; Gudnason, Vilmundur; Hadjichrysanthou, Christoforos; Helmer, Catherine; Ikram, M. Arfan; Ikram, M. Kamran; Kern, Silke; Kuller, Lewis H.; Launer, Lenore; Lopez, Oscar L.; Matthews, Fiona; Meirelles, Osorio; Mosley, Thomas; Ower, Alison; Psaty, Bruce M.; Satizabal, Claudia L.; Seshadri, Sudha; Skoog, Ingmar; Stephan, Blossom C.M.; Tzourio, Christophe; Waziry, Reem; Wong, Mei Mei; Zettergren, Anna; Hofman, Albert
Authors
Frank J. Wolters
Kristoffer Bäckman
Alexa Beiser
Claudine Berr
Joshua C. Bis
Eric Boerwinkle
Daniel Bos
Carol Brayne
Jean Francois Dartigues
Sirwan K.L. Darweesh
Stephanie Debette
Kendra L. Davis-Plourde
Carole Dufouil
Myriam Fornage
Leslie Grasset
Vilmundur Gudnason
Christoforos Hadjichrysanthou
Catherine Helmer
M. Arfan Ikram
M. Kamran Ikram
Silke Kern
Lewis H. Kuller
Lenore Launer
Oscar L. Lopez
Professor Fiona Matthews F.Matthews@hull.ac.uk
Pro-Vice-Chancellor Research and Enterprise
Osorio Meirelles
Thomas Mosley
Alison Ower
Bruce M. Psaty
Claudia L. Satizabal
Sudha Seshadri
Ingmar Skoog
Blossom C.M. Stephan
Christophe Tzourio
Reem Waziry
Mei Mei Wong
Anna Zettergren
Albert Hofman
Abstract
Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or inconclusive with regard to the impact of gender and education with underlying causes of a presumed declining trend remaining largely unidentified. The Alzheimer Cohorts Consortium aggregates data from nine international population-based cohorts to determine changes in the incidence of dementia since 1990. We will employ Poisson regression models to calculate incidence rates in each cohort and Cox proportional hazard regression to compare 5-year cumulative hazards across study-specific epochs. Finally, we will meta-analyse changes per decade across cohorts, and repeat all analysis stratified by sex, education and APOE genotype. In all cohorts combined, there are data on almost 69,000 people at risk of dementia with the range of follow-up years between 2 and 27. The average age at baseline is similar across cohorts ranging between 72 and 77. Uniting a wide range of disease-specific and methodological expertise in research teams, the first analyses within the Alzheimer Cohorts Consortium are underway to tackle outstanding challenges in the assessment of time-trends in dementia occurrence.
Citation
Chibnik, L. B., Wolters, F. J., Bäckman, K., Beiser, A., Berr, C., Bis, J. C., …Hofman, A. (2017). Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium. European Journal of Epidemiology, 32(10), 931-938. https://doi.org/10.1007/s10654-017-0320-5
Journal Article Type | Article |
---|---|
Publication Date | Oct 1, 2017 |
Deposit Date | Dec 8, 2023 |
Journal | European Journal of Epidemiology |
Print ISSN | 0393-2990 |
Electronic ISSN | 1573-7284 |
Publisher | Springer |
Volume | 32 |
Issue | 10 |
Pages | 931-938 |
DOI | https://doi.org/10.1007/s10654-017-0320-5 |
Public URL | https://hull-repository.worktribe.com/output/4452926 |
You might also like
Downloadable Citations
About Repository@Hull
Administrator e-mail: repository@hull.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search