Dávid Samu
Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity
Samu, Dávid; Campbell, Karen L.; Tsvetanov, Kamen A.; Shafto, Meredith A.; Brayne, Carol; Bullmore, Edward T.; Calder, Andrew C.; Cusack, Rhodri; Dalgleish, Tim; Duncan, John; Henson, Richard N.; Matthews, Fiona E.; Marslen-Wilson, William D.; Rowe, James B.; Cheung, Teresa; Davis, Simon; Geerligs, Linda; Kievit, Rogier; McCarrey, Anna; Mustafa, Abdur; Price, Darren; Taylor, Jason R.; Treder, Matthias; Van Belle, Janna; Williams, Nitin; Bates, Lauren; Emery, Tina; Erzinclioglu, Sharon; Gadie, Andrew; Gerbase, Sofia; Georgieva, Stanimira; Hanley, Claire; Parkin, Beth; Troy, David; Auer, Tibor; Correia, Marta; Gao, Lu; Green, Emma; Henriques, Rafael; Allen, Jodie; Amery, Gillian; Amunts, Liana; Barcroft, Anne; Castle, Amanda; DIas, Cheryl; Dowrick, Jonathan; Fair, Melissa; Fisher, Hayley; Goulding, Anna; Grewal, Adarsh; Hale, Geoff; Hilton, Andrew; Johnson, Frances; Johnston, Patricia; Kavanagh-Williamson, Thea; Kwasniewska, Magdalena; McMinn, Alison; Norman, Kim; Penrose, Jessica; Roby,...
Authors
Karen L. Campbell
Kamen A. Tsvetanov
Meredith A. Shafto
Carol Brayne
Edward T. Bullmore
Andrew C. Calder
Rhodri Cusack
Tim Dalgleish
John Duncan
Richard N. Henson
Professor Fiona Matthews F.Matthews@hull.ac.uk
Pro-Vice-Chancellor Research and Enterprise
William D. Marslen-Wilson
James B. Rowe
Teresa Cheung
Simon Davis
Linda Geerligs
Rogier Kievit
Anna McCarrey
Abdur Mustafa
Darren Price
Jason R. Taylor
Matthias Treder
Janna Van Belle
Nitin Williams
Lauren Bates
Tina Emery
Sharon Erzinclioglu
Andrew Gadie
Sofia Gerbase
Stanimira Georgieva
Claire Hanley
Beth Parkin
David Troy
Tibor Auer
Marta Correia
Lu Gao
Emma Green
Rafael Henriques
Jodie Allen
Gillian Amery
Liana Amunts
Anne Barcroft
Amanda Castle
Cheryl DIas
Jonathan Dowrick
Melissa Fair
Hayley Fisher
Anna Goulding
Adarsh Grewal
Geoff Hale
Andrew Hilton
Frances Johnson
Patricia Johnston
Thea Kavanagh-Williamson
Magdalena Kwasniewska
Alison McMinn
Kim Norman
Jessica Penrose
Fiona Roby
DIane Rowland
John Sargeant
Maggie Squire
Beth Stevens
Aldabra Stoddart
Cheryl Stone
Tracy Thompson
Ozlem Yazlik
Dan Barnes
Marie DIxon
Jaya Hillman
Joanne Mitchell
Laura Villis
Lorraine K. Tyler
Abstract
Healthy ageing has disparate effects on different cognitive domains. The neural basis of these differences, however, is largely unknown. We investigated this question by using Independent Components Analysis to obtain functional brain components from 98 healthy participants aged 23-87 years from the population-based Cam-CAN cohort. Participants performed two cognitive tasks that show age-related decrease (fluid intelligence and object naming) and a syntactic comprehension task that shows age-related preservation. We report that activation of task-positive neural components predicts inter-individual differences in performance in each task across the adult lifespan. Furthermore, only the two tasks that show performance declines with age show age-related decreases in task-positive activation of neural components and decreasing default mode (DM) suppression. Our results suggest that distributed, multi-component brain responsivity supports cognition across the adult lifespan, and the maintenance of this, along with maintained DM deactivation, characterizes successful ageing and may explain differential ageing trajectories across cognitive domains.
Citation
Samu, D., Campbell, K. L., Tsvetanov, K. A., Shafto, M. A., Brayne, C., Bullmore, E. T., …Tyler, L. K. (2017). Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity. Nature communications, 8, https://doi.org/10.1038/ncomms14743
Journal Article Type | Article |
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Publication Date | May 8, 2017 |
Deposit Date | Dec 8, 2023 |
Journal | Nature Communications |
Electronic ISSN | 2041-1723 |
Publisher | Nature Publishing Group |
Volume | 8 |
DOI | https://doi.org/10.1038/ncomms14743 |
Public URL | https://hull-repository.worktribe.com/output/4453118 |
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