Modelling life course blood pressure trajectories using Bayesian adaptive splines

Muniz-Terrera, Graciela; Bakra, Eleni; Hardy, Rebecca; Matthews, Fiona E.; Lunn, David

Abstract

No single study has collected data over individuals' entire lifespans. To understand changes over the entire life course, it is necessary to combine data from various studies that cover the whole life course. Such combination may be methodologically challenging due to potential differences in study protocols, information available and instruments used to measure the outcome of interest. Motivated by our interest in modelling blood pressure changes over the life course, we propose the use of Bayesian adaptive splines within a hierarchical setting to combine data from several UK-based longitudinal studies where blood pressure measures were taken in different stages of life. Our method allowed us to obtain a realistic estimate of the mean life course trajectory, quantify the variability both within and between studies, and examine overall and study specific effects of relevant risk factors on life course blood pressure changes.

Citation

Muniz-Terrera, G., Bakra, E., Hardy, R., Matthews, F. E., & Lunn, D. (2016). Modelling life course blood pressure trajectories using Bayesian adaptive splines. Statistical Methods in Medical Research, 25(6), 2767-2780. https://doi.org/10.1177/0962280214532576

• Journal Article Type: Article
• Publication Date: Dec 1, 2016
• Deposit Date: Dec 8, 2023
• Journal: Statistical Methods in Medical Research
• Print ISSN: 0962-2802
• Electronic ISSN: 1477-0334
• Publisher: SAGE Publications
• Volume: 25
• Issue: 6
• Pages: 2767-2780
• DOI: https://doi.org/10.1177/0962280214532576
• Public URL: https://hull-repository.worktribe.com/output/4453387