SARS-CoV-2 and pancreas: a potential pathological interaction?

Geravandi, Shirin; Mahmoudi-aznaveh, Azam; Azizi, Zahra; Maedler, Kathrin; Ardestani, Amin

Abstract

The widespread extrapulmonary complications of coronavirus disease 2019 (COVID-19) have gained momentum; the pancreas is another major target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we take a closer look into potential pathological interactions. We provide an overview of the current knowledge and understanding of SARS-CoV-2 infection of the pancreas with a special focus on pancreatic islets and propose direct, indirect, and systemic mechanisms for pancreas injury as result of the COVID-19–diabetes fatal bidirectional relationship.

Citation

Geravandi, S., Mahmoudi-aznaveh, A., Azizi, Z., Maedler, K., & Ardestani, A. (2021). SARS-CoV-2 and pancreas: a potential pathological interaction?. Trends in Endocrinology & Metabolism, 32(11), 842-845. https://doi.org/10.1016/j.tem.2021.07.004

• Journal Article Type: Short Survey
• Acceptance Date: Jul 19, 2021
• Online Publication Date: Jul 24, 2021
• Publication Date: Nov 1, 2021
• Deposit Date: Jan 4, 2024
• Publicly Available Date: Feb 7, 2024
• Journal: Trends in Endocrinology and Metabolism
• Print ISSN: 1043-2760
• Electronic ISSN: 1879-3061
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 32
• Issue: 11
• Pages: 842-845
• DOI: https://doi.org/10.1016/j.tem.2021.07.004
• Keywords: COVID-19; SARS-CoV-2; Islets; β-cell; Pancreas; Inflammation; Diabetes; ACE2; Insulin
• Public URL: https://hull-repository.worktribe.com/output/4461517