STRIPAK Is a Regulatory Hub Initiating Hippo Signaling

Ardestani, Amin; Maedler, Kathrin

Abstract

Signaling modules that integrate the diverse extra- and intracellular inputs to the Hippo pathway were previously unknown. By biochemical and molecular interrogation, Chen et al. established a molecular framework, the RhoA-RHPN-NF2/Kibra-STRIPAK axis, that regulates the status of Hippo core kinases and connects upstream signals to initiate and orchestrate the Hippo pathway.

Citation

Ardestani, A., & Maedler, K. (2020). STRIPAK Is a Regulatory Hub Initiating Hippo Signaling. Trends in Biochemical Sciences, 45(4), 280-283. https://doi.org/10.1016/j.tibs.2020.01.005

• Online Publication Date: Feb 15, 2020
• Publication Date: Apr 1, 2020
• Deposit Date: Jan 4, 2024
• Journal: Trends in Biochemical Sciences
• Electronic ISSN: 1362-4326
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 45
• Issue: 4
• Pages: 280-283
• DOI: https://doi.org/10.1016/j.tibs.2020.01.005
• Public URL: https://hull-repository.worktribe.com/output/4461588