Loss of TAZ Boosts PPARγ to Cope with Insulin Resistance

Ardestani, Amin; Maedler, Kathrin

Abstract

In this issue of Cell Metabolism, El Ouarrat et al. identify the Hippo signaling terminal effector TAZ as an endogenous negative regulator of PPARγ, a master transcriptional regulator of lipid metabolism and insulin sensitivity. Selective destruction of TAZ in adipocytes lowers inflammation and restores insulin sensitivity and glucose homeostasis.

Citation

Ardestani, A., & Maedler, K. (2020). Loss of TAZ Boosts PPARγ to Cope with Insulin Resistance. Cell Metabolism, 31(1), 6-8. https://doi.org/10.1016/j.cmet.2019.12.006

• Journal Article Type: Note
• Online Publication Date: Jan 7, 2020
• Publication Date: Jan 7, 2020
• Deposit Date: Jan 4, 2024
• Journal: Cell metabolism
• Print ISSN: 1550-4131
• Electronic ISSN: 1932-7420
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 31
• Issue: 1
• Pages: 6-8
• DOI: https://doi.org/10.1016/j.cmet.2019.12.006
• Public URL: https://hull-repository.worktribe.com/output/4461592