Dr Amin Ardestani A.Ardestani@hull.ac.uk
Senior Lecturer
mTORC1 and IRS1: Another Deadly Kiss
Ardestani, Amin; Maedler, Kathrin
Authors
Kathrin Maedler
Abstract
Mechanistic target of rapamycin complex (mTORC)1 is the major regulator of metabolism at the cellular and organismal level. mTORC1-mediated regulatory feedback loops enable adaptation to nutrient and growth factor availability and metabolic demand. In their recent study, Yoneyama et al. have identified and characterized a negative feedback loop from mTORC1 to insulin receptor substrate (IRS)1; the key component of the insulin/insulin-like growth factor (IGF) signaling pathway.
Citation
Ardestani, A., & Maedler, K. (2018). mTORC1 and IRS1: Another Deadly Kiss. Trends in Endocrinology & Metabolism, 29(11), 737-739. https://doi.org/10.1016/j.tem.2018.07.003
Online Publication Date | Aug 3, 2018 |
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Publication Date | Nov 1, 2018 |
Deposit Date | Jan 4, 2024 |
Journal | Trends in Endocrinology and Metabolism |
Print ISSN | 1043-2760 |
Electronic ISSN | 1879-3061 |
Publisher | Cell Press |
Peer Reviewed | Peer Reviewed |
Volume | 29 |
Issue | 11 |
Pages | 737-739 |
DOI | https://doi.org/10.1016/j.tem.2018.07.003 |
Public URL | https://hull-repository.worktribe.com/output/4461624 |
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