mTORC1 and IRS1: Another Deadly Kiss

Ardestani, Amin; Maedler, Kathrin

Abstract

Mechanistic target of rapamycin complex (mTORC)1 is the major regulator of metabolism at the cellular and organismal level. mTORC1-mediated regulatory feedback loops enable adaptation to nutrient and growth factor availability and metabolic demand. In their recent study, Yoneyama et al. have identified and characterized a negative feedback loop from mTORC1 to insulin receptor substrate (IRS)1; the key component of the insulin/insulin-like growth factor (IGF) signaling pathway.

Citation

Ardestani, A., & Maedler, K. (2018). mTORC1 and IRS1: Another Deadly Kiss. Trends in Endocrinology & Metabolism, 29(11), 737-739. https://doi.org/10.1016/j.tem.2018.07.003

• Online Publication Date: Aug 3, 2018
• Publication Date: Nov 1, 2018
• Deposit Date: Jan 4, 2024
• Journal: Trends in Endocrinology and Metabolism
• Print ISSN: 1043-2760
• Electronic ISSN: 1879-3061
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Issue: 11
• Pages: 737-739
• DOI: https://doi.org/10.1016/j.tem.2018.07.003
• Public URL: https://hull-repository.worktribe.com/output/4461624