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mTORC in β cells: More Than Only Recognizing Comestibles

Maedler, Kathrin; Ardestani, Amin

Authors

Kathrin Maedler



Abstract

The pathways regulating pancreatic β cell survival in diabetes are poorly understood. Here, Chau et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701085) demonstrate that mTOR regulates the apoptotic machinery through binding to the ChREBP- Mlx complex to suppress TXN IP, thereby protecting pancreatic β cells in the diabetic setting by inhibiting oxidative stress and mitochondrial dysfunction.

Citation

Maedler, K., & Ardestani, A. (2017). mTORC in β cells: More Than Only Recognizing Comestibles. Journal of Cell Biology, 216(7), 1883-1885. https://doi.org/10.1083/jcb.201704179

Journal Article Type Article
Online Publication Date Jun 12, 2017
Publication Date Jul 1, 2017
Deposit Date Jan 4, 2024
Publicly Available Date Jan 8, 2024
Journal Journal of Cell Biology
Print ISSN 0021-9525
Electronic ISSN 1540-8140
Publisher Rockefeller University Press
Peer Reviewed Peer Reviewed
Volume 216
Issue 7
Pages 1883-1885
DOI https://doi.org/10.1083/jcb.201704179
Keywords Cell signaling; Metabolism
Public URL https://hull-repository.worktribe.com/output/4461660

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Publisher Licence URL
http://creativecommons.org/licenses/by-nc-sa/4.0/

Copyright Statement
© 2017 Maedler and Ardestani This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).




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