A randomized trial comparing treatments for varicose veins.

Brittenden, Julie; Cotton, Seonaidh C.; Elders, Andrew; Ramsay, Craig R.; Norrie, John; Burr, Jennifer; Campbell, Bruce; Bachoo, Paul; Chetter, Ian; Gough, Michael; Earnshaw, Jonothan; Lees, Tim; Scott, Julian; Baker, Sara A.; Francis, Jill; Tassie, Emma; Scotland, Graham; Wileman, Samantha; Campbell, Marion K.

Abstract

BACKGROUND
Ultrasound-guided foam sclerotherapy and endovenous laser ablation are widely used alternatives to surgery for the treatment of varicose veins, but their comparative effectiveness and safety remain uncertain.

METHODS
In a randomized trial involving 798 participants with primary varicose veins at 11 centers in the United Kingdom, we compared the outcomes of foam, laser, and surgical treatments. Primary outcomes at 6 months were disease-specific quality of life and generic quality of life, as measured on several scales. Secondary outcomes included complications and measures of clinical success.

Citation

Brittenden, J., Cotton, S. C., Elders, A., Ramsay, C. R., Norrie, J., Burr, J., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., Francis, J., Tassie, E., Scotland, G., Wileman, S., & Campbell, M. K. (2014). A randomized trial comparing treatments for varicose veins. New England Journal of Medicine, 371, 1218-1227. https://doi.org/10.1056/NEJMoa1400781

• Journal Article Type: Article
• Publication Date: Sep 25, 2014
• Deposit Date: Mar 8, 2017
• Journal: N Engl J Med
• Electronic ISSN: 1533-4406
• Publisher: Massachusetts Medical Society
• Peer Reviewed: Not Peer Reviewed
• Volume: 371
• Pages: 1218-1227
• DOI: https://doi.org/10.1056/NEJMoa1400781
• Public URL: https://hull-repository.worktribe.com/output/449208
• Contract Date: Mar 8, 2017