Skip to main content

Research Repository

Advanced Search

Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics

Cuthbert, Joseph James; Clark, Andrew L.

Authors

Andrew L. Clark



Abstract

Purpose of Review: Fluid retention or congestion is a major cause of symptoms, poor quality of life, and adverse outcome in patients with heart failure (HF). Despite advances in disease-modifying therapy, the mainstay of treatment for congestion—loop diuretics—has remained largely unchanged for 50 years. In these two articles (part I: loop diuretics and part II: combination therapy), we will review the history of diuretic treatment and the current trial evidence for different diuretic strategies and explore potential future directions of research.
Recent Findings: We will assess recent trials including DOSE, TRANSFORM, ADVOR, CLOROTIC, OSPREY-AHF, and PUSH-AHF amongst others, and assess how these may influence current practice and future research.
Summary: There are few data on which to base diuretic therapy in clinical practice. The most robust evidence is for high dose loop diuretic treatment over low-dose treatment for patients admitted to hospital with HF, yet this is not reflected in guidelines. There is an urgent need for more and better research on different diuretic strategies in patients with HF.

Citation

Cuthbert, J. J., & Clark, A. L. (2024). Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics. Current Heart Failure Reports, 21(2), 101-114. https://doi.org/10.1007/s11897-024-00643-3

Journal Article Type Review
Acceptance Date Jan 3, 2024
Online Publication Date Jan 19, 2024
Publication Date 2024-04
Deposit Date Jan 24, 2024
Publicly Available Date May 7, 2024
Journal Current Heart Failure Reports
Print ISSN 1546-9530
Electronic ISSN 1546-9549
Publisher Springer
Peer Reviewed Peer Reviewed
Volume 21
Issue 2
Pages 101-114
DOI https://doi.org/10.1007/s11897-024-00643-3
Keywords Physiology (medical); Cardiology and Cardiovascular Medicine; Emergency Medicine
Public URL https://hull-repository.worktribe.com/output/4524998

Files

Published paper (1.4 Mb)
PDF

Publisher Licence URL
http://creativecommons.org/licenses/by/4.0

Copyright Statement
© The Author(s) 2024
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long
as you give appropriate credit to the original author(s) and the source,
provide a link to the Creative Commons licence, and indicate if changes
were made.





You might also like



Downloadable Citations