A quinoline-based fluorometric and colorimetric dual-modal pH probe and its application in bioimaging

Redshaw, Carl.; Li, Zhao.; Mu, Lan.; Wei, Gang.; Zeng, Xi.; Zhu, Qin.

doi:10.1016/j.saa.2017.06.071

Authors

Qin Zhu

Zhao Li

Lan Mu

Xi Zeng

Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry

Gang Wei

Abstract

The compound (E)-8-hydroxyl-2-[(E)-2-(2, 4-dihydroxyphenyl)vinyl]-quinoline (1) has been developed as a fluorometric and colorimetric dual-modal probe for pH detection in solution and in vivo. Remarkable changes in the fluorescence intensity with large Stokes shifts and colorimetric responses were observed as a function of pH. The sensing mechanisms involving protonation and deprotonation processes over the acidic and alkaline pH ranges were confirmed by 1H NMR and IR spectroscopic analysis. Furthermore, the application of probe 1 for the imaging of live PC3 cells was successfully achieved. Test strips based on probe 1 were fabricated, and were found to act as a convenient and efficient pH test kits.

Journal Article Type	Article
Publication Date	Jan 5, 2018
Journal	Spectrochimica acta part A : molecular and biomolecular spectroscopy
Print ISSN	1386-1425
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	188
Pages	230-236
Institution Citation	Zhu, Q., Li, Z., Mu, L., Zeng, X., Redshaw, C., & Wei, G. (2018). A quinoline-based fluorometric and colorimetric dual-modal pH probe and its application in bioimaging. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 188, (230-236). doi:10.1016/j.saa.2017.06.071. ISSN 1386-1425
DOI	https://doi.org/10.1016/j.saa.2017.06.071
Keywords	Quinoline; pH probe; Fluorometric; Colorimetric; Bioimaging
Publisher URL	http://www.sciencedirect.com/science/article/pii/S1386142517305486?via%3Dihub
Copyright Statement	©2018, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Additional Information	This is the accepted manuscript of an article published in Spectrochimica acta part A : molecular and biomolecular spectroscopy, 2018. The version of record is available at the DOI link in this record.

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Copyright Statement
©2018, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/