Professor Carl Redshaw C.Redshaw@hull.ac.uk
The compound (E)-8-hydroxyl-2-[(E)-2-(2, 4-dihydroxyphenyl)vinyl]-quinoline (1) has been developed as a fluorometric and colorimetric dual-modal probe for pH detection in solution and in vivo. Remarkable changes in the fluorescence intensity with large Stokes shifts and colorimetric responses were observed as a function of pH. The sensing mechanisms involving protonation and deprotonation processes over the acidic and alkaline pH ranges were confirmed by 1H NMR and IR spectroscopic analysis. Furthermore, the application of probe 1 for the imaging of live PC3 cells was successfully achieved. Test strips based on probe 1 were fabricated, and were found to act as a convenient and efficient pH test kits.
| Journal Article Type | Article |
| Publication Date | Jan 5, 2018 |
| Journal | Spectrochimica acta part A : molecular and biomolecular spectroscopy |
| Print ISSN | 1386-1425 |
| Publisher | Elsevier |
| Peer Reviewed | Peer Reviewed |
| Volume | 188 |
| Pages | 230-236 |
| DOI | https://doi.org/10.1016/j.saa.2017.06.071 |
| Keywords | Quinoline; pH probe; Fluorometric; Colorimetric; Bioimaging |
| Publisher URL | http://www.sciencedirect.com/science/article/pii/S1386142517305486?via%3Dihub |
| Copyright Statement | ©2018, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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