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Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency

Gonzalez, S.; Windram, J. D.; Clark, AL; Atkin, S. L.; Sathyapalan, T.; Javed, Z.; Clark, Andrew; Javed, Zeeshan; Sathyapalan, Thozhukat; Atkin, Stephen; Gonzalez, Susana; Windram, Hull

Authors

S. Gonzalez

J. D. Windram

AL Clark

S. L. Atkin

T. Sathyapalan

Z. Javed

Andrew Clark

Zeeshan Javed

Thozhukat Sathyapalan

Stephen Atkin

Susana Gonzalez

Hull Windram



Abstract

Objective Epidemiological studies suggest that adult-onset growth hormone deficiency (AGHD) might increase the risk of death from cardiovascular causes. Methods This was a 6-month double-blind, placebo-controlled, randomised, cross-over trial followed by a 6-month open-label phase. Seventeen patients with AGHD received either recombinant human growth hormone (rGH) (0.4 mg injection daily) or placebo for 12 weeks, underwent washout for 2 weeks, and were then crossed over to the alternative treatment for a further 12 weeks. Cardiac magnetic resonance imaging, echocardiography, and cardiopulmonary exercise testing were performed at baseline, 12 weeks, 26 weeks, and the end of the open phase (12 months). The results were compared with those of 16 age- and sex-matched control subjects. Results At baseline, patients with AGHD had a significantly higher systolic blood pressure, ejection fraction, and left ventricular mass than the control group, even when corrected for body surface area. Treatment with rGH normalised the insulin-like growth factor 1 concentration without an effect on exercise capacity, cardiac structure, or cardiac function. Conclusion Administration of rGH therapy for 6 to 9 months failed to normalise the functional and structural cardiac differences observed in patients with AGHD when compared with a control group.

Citation

Gonzalez, S., Windram, J. D., Clark, A., Atkin, S. L., Sathyapalan, T., Javed, Z., …Windram, H. (2017). Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency. Journal of International Medical Research, 45(6), 1708-1719. doi:10.1177/0300060517723798

Journal Article Type Article
Acceptance Date Jul 11, 2017
Online Publication Date Aug 31, 2017
Publication Date Dec 1, 2017
Deposit Date Sep 28, 2017
Publicly Available Date Sep 28, 2017
Journal Journal of international medical research
Electronic ISSN 1473-2300
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 45
Issue 6
Pages 1708-1719
DOI https://doi.org/10.1177/0300060517723798
Keywords Growth hormone, Adult-onset growth hormone deficiency, Hypopituitarism, Cardiac magnetic resonance imaging, Exercise capacity, Cardiac structure, Cardiac function
Public URL https://hull-repository.worktribe.com/output/455280
Publisher URL http://journals.sagepub.com/doi/10.1177/0300060517723798#articleCitationDownloadContainer
Copyright Statement This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecomm...rg/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/...m/open-access-at-sage).
Additional Information Copy of article published in: Journal of international medical research, 2017

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This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).


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Copyright Statement
This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).





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