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Heart failure - what's new and what's changed?

Callan, Paul D.; Clark, Andrew L.


Paul D. Callan

Andrew L. Clark


Physicians responsible for the care of patients with heart failure due to left ventricular systolic dysfunction have access to a broad range of evidence-based treatments that prolong life and reduce symptoms. In spite of the significant progress made over the last four decades, there is an ongoing need for novel therapies to treat a condition that is associated with stubbornly high morbidity and mortality. In this article, we discuss the findings of SERVE-HF, a randomised controlled trial of adaptive servo-ventilation in patients with left ventricular systolic dysfunction, as well as EMPA-REG, a study of the effects of a novel diabetic agent that may be of greater interest to heart failure specialists than diabetologists. We also examine further analyses of the groundbreaking PARADIGM-HF trial, which attempt to answer some of the unresolved questions from the original study of the first combined angiotensin-receptor blocker and neprilysin inhibitor, sacubitril valsartan. The recently published National Institute for Health and Care Excellence guidelines for the management of acute heart failure and plans to introduce best practice tariffs bring into focus the need for well-organised, multidisciplinary care. We discuss the challenges involved in developing and delivering a specialist service that meets the needs of a growing population of patients living with heart failure.

Journal Article Type Review
Publication Date Aug 1, 2017
Journal Clinical medicine
Print ISSN 1470-2118
Electronic ISSN 1473-4893
Publisher Royal College of Physicians
Peer Reviewed Peer Reviewed
Volume 16
Issue Suppl_6
Pages s37-s42
APA6 Citation Callan, P. D., & Clark, A. L. (2017). Heart failure - what's new and what's changed?. Clinical Medicine, 16(Suppl_6), s37-s42. doi:10.7861/clinmedicine.16-6-s37
Keywords Adaptive servo-ventilation; Angiotensin receptor neprilysin inhibitors; Clinical trials; Diabetes mellitus; Heart failure; Organisation of care
Publisher URL
Related Public URLs Also published at: http://www.clinmed.rcpj...ntent/17/4/341.abstract
Additional Information This is a description of an article published in Clinical medicine, 2017, v.17 issue 4. This article was originally published in the 2016 Clinical Medicine supplement Horizons in Medicine 28. All articles in this supplement are available at

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