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Environmental factors influence cross-talk between a heat shock protein and an oxidative stress protein modification in the lizard Gallotia galloti

Gilbert, Edward; Žagar, Anamarija; López-Darias, Marta; Megía-Palma, Rodrigo; Lister, Karen A.; Jones, Max Dolton; Carretero, Miguel A.; Serén, Nina; Beltran-Alvarez, Pedro; Wollenberg Valero, Katharina C.

Authors

Edward Gilbert

Anamarija Žagar

Marta López-Darias

Rodrigo Megía-Palma

Karen A. Lister

Max Dolton Jones

Miguel A. Carretero

Nina Serén

Profile image of Pedro Beltran-Alvarez

Dr Pedro Beltran-Alvarez P.Beltran-Alvarez@hull.ac.uk
Senior Lecturer in Health and Climate Change and Programme co-Director of the MSc Health and Climate Change

Katharina C. Wollenberg Valero



Abstract

Better understanding how organisms respond to their abiotic environment, especially at the biochemical level, is critical in predicting population trajectories under climate change. In this study, we measured constitutive stress biomarkers and protein post-translational modifications associated with oxidative stress in Gallotia galloti, an insular lizard species inhabiting highly heterogeneous environments on Tenerife. Tenerife is a small volcanic island in a relatively isolated archipelago off the West coast of Africa. We found that expression of GRP94, a molecular chaperone protein, and levels of protein carbonylation, a marker of cellular stress, change across different environments, depending on solar radiation-related variables and topology. Here, we report in a wild animal population, cross-talk between the baseline levels of the heat shock protein-like GRP94 and oxidative damage (protein carbonylation), which are influenced by a range of available temperatures, quantified through modelled operative temperature. This suggests a dynamic trade-off between cellular homeostasis and oxidative damage in lizards adapted to this thermally and topologically heterogeneous environment.

Citation

Gilbert, E., Žagar, A., López-Darias, M., Megía-Palma, R., Lister, K. A., Jones, M. D., …Wollenberg Valero, K. C. (2024). Environmental factors influence cross-talk between a heat shock protein and an oxidative stress protein modification in the lizard Gallotia galloti. PLoS ONE, 19(3 March), Article e0300111. https://doi.org/10.1371/journal.pone.0300111

Journal Article Type Article
Acceptance Date Feb 21, 2024
Online Publication Date Mar 12, 2024
Publication Date Mar 1, 2024
Deposit Date Mar 6, 2024
Publicly Available Date Mar 15, 2024
Journal PLoS ONE
Print ISSN 1932-6203
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 19
Issue 3 March
Article Number e0300111
DOI https://doi.org/10.1371/journal.pone.0300111
Public URL https://hull-repository.worktribe.com/output/4574535

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0

Copyright Statement
Copyright: © 2024 Gilbert et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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