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A Cross-Sectional Study of Protein Changes Associated with Dementia in Non-Obese Weight Matched Women with and without Polycystic Ovary Syndrome

Butler, Alexandra E.; Moin, Abu Saleh Md; Sathyapalan, Thozhukat; Atkin, Stephen L.

Authors

Alexandra E. Butler

Abu Saleh Md Moin

Stephen L. Atkin



Abstract

Dysregulated Alzheimer’s disease (AD)-associated protein expression is reported in polycystic ovary syndrome (PCOS), paralleling the expression reported in type 2 diabetes (T2D). We hypothesized, however, that these proteins would not differ between women with non-obese and non-insulin resistant PCOS compared to matched control subjects. We measured plasma amyloid-related proteins levels (Amyloid-precursor protein (APP), alpha-synuclein (SNCA), amyloid P-component (APCS), Pappalysin (PAPPA), Microtubule-associated protein tau (MAPT), apolipoprotein E (apoE), apoE2, apoE3, apoE4, Serum amyloid A (SAA), Noggin (NOG) and apoA1) in weight and aged-matched non-obese PCOS (n = 24) and control (n = 24) women. Dementia-related proteins fibronectin (FN), FN1.3, FN1.4, Von Willebrand factor (VWF) and extracellular matrix protein 1 (ECM1) were also measured. Protein levels were determined by Slow Off-rate Modified Aptamer (SOMA)-scan plasma protein measurement. Only APCS differed between groups, being elevated in non-obese PCOS women (p = 0.03) relative to the non-obese control women. This differed markedly from the elevated APP, APCS, ApoE, FN, FN1.3, FN1.4 and VWF reported in obese women with PCOS. Non-obese, non-insulin resistant PCOS subjects have a lower AD-associated protein pattern risk profile versus obese insulin resistant PCOS women, and are not dissimilar to non-obese controls, indicating that lifestyle management to maintain optimal body weight could be beneficial to reduce the long-term AD-risk in women with PCOS.

Citation

Butler, A. E., Moin, A. S. M., Sathyapalan, T., & Atkin, S. L. (2024). A Cross-Sectional Study of Protein Changes Associated with Dementia in Non-Obese Weight Matched Women with and without Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 25(4), Article 2409. https://doi.org/10.3390/ijms25042409

Journal Article Type Article
Acceptance Date Jan 16, 2024
Online Publication Date Jan 18, 2024
Publication Date Feb 2, 2024
Deposit Date Mar 17, 2024
Publicly Available Date Mar 19, 2024
Journal International Journal of Molecular Sciences
Electronic ISSN 1422-0067
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 25
Issue 4
Article Number 2409
DOI https://doi.org/10.3390/ijms25042409
Keywords Polycystic ovary syndrome; PCOS; Amyloid-associated proteins; Alzheimer’s disease
Public URL https://hull-repository.worktribe.com/output/4577793

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0

Copyright Statement
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).




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