fMRI reveals greater within- than between-hemifield integration in the human lateral occipital cortex

Large, Mary-Ellen; Aldcroft, Adrian; Culham, Jody; Kuchinad, Anil; Vilis, Tutis

Abstract

Early visual areas within each hemisphere (V1, V2, V3/VP, V4v) contain distinct representations of the upper and lower quadrants of the contralateral hemifield. As receptive field size increases, the retinotopy in higher-tier visual areas becomes progressively less distinct. Using functional magnetic resonance imaging (fMRI) to map the visual fields, we found that an intermediate level visual area, the lateral occipital region (LO), contains retinotopic maps with a contralateral bias, but with a combined representation of the upper and lower visual field. Moreover, we used the technique of fMRI adaptation to determine whether neurons in LO code for both the upper and lower contralateral quadrants. We found that even when visual stimulus locations are equivalent across comparisons, the LO was more sensitive to location changes that crossed hemifields than location changes within a hemifield. These results suggested that within high-tier visual areas the increasing integration of visual field information is a two-stage process. The upper and lower visual representations are combined first, in LO, then the left and right representations. Furthermore, these results provided evidence for a neural mechanism to explain behavioral findings of greater integration within than between hemifields.

Citation

Large, M.-E., Aldcroft, A., Culham, J., Kuchinad, A., & Vilis, T. (2008). fMRI reveals greater within- than between-hemifield integration in the human lateral occipital cortex. The European journal of neuroscience, 27(12), 3299-3309. https://doi.org/10.1111/j.1460-9568.2008.06270.x

• Journal Article Type: Article
• Acceptance Date: Apr 17, 2018
• Online Publication Date: Jun 28, 2018
• Publication Date: 2008-05
• Deposit Date: Nov 13, 2014
• Journal: European Journal Of Neuroscience
• Print ISSN: 0953-816X
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 27
• Issue: 12
• Pages: 3299-3309
• DOI: https://doi.org/10.1111/j.1460-9568.2008.06270.x
• Keywords: General Neuroscience
• Public URL: https://hull-repository.worktribe.com/output/460642
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1460-9568.2008.06270.x
• Contract Date: Nov 13, 2014