Margarita Strimaite
Layered rare-earth hydroxides as multi-modal medical imaging probes: particle size optimisation and compositional exploration
Strimaite, Margarita; Wells, Connor J.R.; Prior, Timothy J.; Stuckey, Daniel J.; Wells, Jack A.; Davies, Gemma Louise; Williams, Gareth R.
Authors
Connor J.R. Wells
Dr Tim Prior T.Prior@hull.ac.uk
Senior Lecturer in Inorganic Chemistry
Daniel J. Stuckey
Jack A. Wells
Gemma Louise Davies
Gareth R. Williams
Abstract
Recently, layered rare-earth hydroxides (LRHs) have received growing attention in the field of theranostics. We have previously reported the hydrothermal synthesis of layered terbium hydroxide (LTbH), which exhibited high biocompatibility, reversible uptake of a range of model drugs, and release-sensitive phosphorescence. Despite these favourable properties, LTbH particles produced by the reported method suffered from poor size-uniformity (670 ± 564 nm), and are thus not suitable for therapeutic applications. To ameliorate this issue, we first derive an optimised hydrothermal synthesis method to generate LTbH particles with a high degree of homogeneity and reproducibility, within a size range appropriate for in vivo applications (152 ± 59 nm, n = 6). Subsequently, we apply this optimised method to synthesise a selected range of LRH materials (R = Pr, Nd, Gd, Dy, Er, Yb), four of which produced particles with an average size under 200 nm (Pr, Nd, Gd, and Dy) without the need for further optimisation. Finally, we incorporate Gd and Tb into LRHs in varying molar ratios (1 : 3, 1 : 1, and 3 : 1) and assess the combined magnetic relaxivity and phosphorescence properties of the resultant LRH materials. The lead formulation, LGd1.41Tb0.59H, was demonstrated to significantly shorten the T2 relaxation time of water (r2 = 52.06 mM−1 s−1), in addition to exhibiting a strong phosphorescence signal (over twice that of the other LRH formulations, including previously reported LTbH), therefore holding great promise as a potential multi-modal medical imaging probe.
Citation
Strimaite, M., Wells, C. J., Prior, T. J., Stuckey, D. J., Wells, J. A., Davies, G. L., & Williams, G. R. (2024). Layered rare-earth hydroxides as multi-modal medical imaging probes: particle size optimisation and compositional exploration. Dalton Transactions : an international journal of inorganic chemistry, 53(19), 8429-8442. https://doi.org/10.1039/d4dt00371c
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 19, 2024 |
Online Publication Date | Apr 19, 2024 |
Publication Date | May 21, 2024 |
Deposit Date | Apr 30, 2024 |
Publicly Available Date | May 1, 2024 |
Journal | Dalton Transactions |
Print ISSN | 1477-9226 |
Electronic ISSN | 1477-9234 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 53 |
Issue | 19 |
Pages | 8429-8442 |
DOI | https://doi.org/10.1039/d4dt00371c |
Public URL | https://hull-repository.worktribe.com/output/4652661 |
Files
Published article
(2.3 Mb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by/3.0
Copyright Statement
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
You might also like
Co/Mn-based 2D coordination polymers: synthesis, structure and ring opening polymerization
(2023)
Journal Article
A cucurbit[8]uril-based fluorescent probe for the selective detection of pymetrozine
(2023)
Journal Article
Supramolecular Self-assemblies of inverted cucurbit[6]uril with 1,5-pentanediamine
(2023)
Journal Article
Downloadable Citations
About Repository@Hull
Administrator e-mail: repository@hull.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search