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CPMV-DOX delivers

Aljabali, Alaa A. A.; Shukla, Sourabh; Lomonossoff, George P.; Steinmetz, Nicole F.; Evans, David J.

Authors

Alaa A. A. Aljabali

Sourabh Shukla

George P. Lomonossoff

Nicole F. Steinmetz

David J. Evans



Abstract

The plant virus, Cowpea mosaic virus (CPMV), is developed as a carrier of the chemotherapeutic drug doxorubicin (DOX). CPMV-DOX conjugate, in which eighty DOX molecules are covalently bound to external surface carboxylates of the viral nanoparticle (VNP), shows greater cytotoxicity than free DOX toward HeLa cells when administered at low dosage. At higher concentrations, CPMV-DOX cytotoxicity is time-delayed. The CPMV conjugate is targeted to the endolysosomal compartment of the cells, in which the proteinaceous drug carrier is degraded and the drug released. This study is the first demonstrating the utility of CPMV as a drug delivery vehicle.

Citation

Aljabali, A. A. A., Shukla, S., Lomonossoff, G. P., Steinmetz, N. F., & Evans, D. J. (2013). CPMV-DOX delivers. Molecular pharmaceutics, 10(1), 3-10. https://doi.org/10.1021/mp3002057

Journal Article Type Article
Acceptance Date Jul 24, 2012
Online Publication Date Aug 6, 2012
Publication Date Jan 7, 2013
Deposit Date Nov 13, 2014
Publicly Available Date Mar 29, 2024
Journal Molecular Pharmaceutics
Print ISSN 1543-8384
Electronic ISSN 1543-8392
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 10
Issue 1
Pages 3-10
DOI https://doi.org/10.1021/mp3002057
Keywords Cowpea mosaic virus; Doxorubicin; Drug-delivery
Public URL https://hull-repository.worktribe.com/output/466743
Publisher URL https://pubs.acs.org/doi/10.1021/mp3002057