Alaa A. A. Aljabali
CPMV-DOX delivers
Aljabali, Alaa A. A.; Shukla, Sourabh; Lomonossoff, George P.; Steinmetz, Nicole F.; Evans, David J.
Authors
Sourabh Shukla
George P. Lomonossoff
Nicole F. Steinmetz
David J. Evans
Abstract
The plant virus, Cowpea mosaic virus (CPMV), is developed as a carrier of the chemotherapeutic drug doxorubicin (DOX). CPMV-DOX conjugate, in which eighty DOX molecules are covalently bound to external surface carboxylates of the viral nanoparticle (VNP), shows greater cytotoxicity than free DOX toward HeLa cells when administered at low dosage. At higher concentrations, CPMV-DOX cytotoxicity is time-delayed. The CPMV conjugate is targeted to the endolysosomal compartment of the cells, in which the proteinaceous drug carrier is degraded and the drug released. This study is the first demonstrating the utility of CPMV as a drug delivery vehicle.
Citation
Aljabali, A. A. A., Shukla, S., Lomonossoff, G. P., Steinmetz, N. F., & Evans, D. J. (2013). CPMV-DOX delivers. Molecular pharmaceutics, 10(1), 3-10. https://doi.org/10.1021/mp3002057
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 24, 2012 |
Online Publication Date | Aug 6, 2012 |
Publication Date | Jan 7, 2013 |
Deposit Date | Nov 13, 2014 |
Journal | Molecular Pharmaceutics |
Print ISSN | 1543-8384 |
Electronic ISSN | 1543-8392 |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 10 |
Issue | 1 |
Pages | 3-10 |
DOI | https://doi.org/10.1021/mp3002057 |
Keywords | Cowpea mosaic virus; Doxorubicin; Drug-delivery |
Public URL | https://hull-repository.worktribe.com/output/466743 |
Publisher URL | https://pubs.acs.org/doi/10.1021/mp3002057 |
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