CPMV-DOX delivers

Aljabali, Alaa A. A.; Shukla, Sourabh; Lomonossoff, George P.; Steinmetz, Nicole F.; Evans, David J.

Abstract

The plant virus, Cowpea mosaic virus (CPMV), is developed as a carrier of the chemotherapeutic drug doxorubicin (DOX). CPMV-DOX conjugate, in which eighty DOX molecules are covalently bound to external surface carboxylates of the viral nanoparticle (VNP), shows greater cytotoxicity than free DOX toward HeLa cells when administered at low dosage. At higher concentrations, CPMV-DOX cytotoxicity is time-delayed. The CPMV conjugate is targeted to the endolysosomal compartment of the cells, in which the proteinaceous drug carrier is degraded and the drug released. This study is the first demonstrating the utility of CPMV as a drug delivery vehicle.

Citation

Aljabali, A. A. A., Shukla, S., Lomonossoff, G. P., Steinmetz, N. F., & Evans, D. J. (2013). CPMV-DOX delivers. Molecular pharmaceutics, 10(1), 3-10. https://doi.org/10.1021/mp3002057

• Journal Article Type: Article
• Acceptance Date: Jul 24, 2012
• Online Publication Date: Aug 6, 2012
• Publication Date: Jan 7, 2013
• Deposit Date: Nov 13, 2014
• Journal: Molecular Pharmaceutics
• Print ISSN: 1543-8384
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 1
• Pages: 3-10
• DOI: https://doi.org/10.1021/mp3002057
• Keywords: Cowpea mosaic virus; Doxorubicin; Drug-delivery
• Public URL: https://hull-repository.worktribe.com/output/466743
• Publisher URL: https://pubs.acs.org/doi/10.1021/mp3002057
• Contract Date: Nov 23, 2017