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CPMV-DOX delivers

Aljabali, Alaa A. A.; Shukla, Sourabh; Lomonossoff, George P.; Steinmetz, Nicole F.; Evans, David J.


Alaa A. A. Aljabali

Sourabh Shukla

George P. Lomonossoff

Nicole F. Steinmetz

David J. Evans


The plant virus, Cowpea mosaic virus (CPMV), is developed as a carrier of the chemotherapeutic drug doxorubicin (DOX). CPMV-DOX conjugate, in which eighty DOX molecules are covalently bound to external surface carboxylates of the viral nanoparticle (VNP), shows greater cytotoxicity than free DOX toward HeLa cells when administered at low dosage. At higher concentrations, CPMV-DOX cytotoxicity is time-delayed. The CPMV conjugate is targeted to the endolysosomal compartment of the cells, in which the proteinaceous drug carrier is degraded and the drug released. This study is the first demonstrating the utility of CPMV as a drug delivery vehicle.


Aljabali, A. A. A., Shukla, S., Lomonossoff, G. P., Steinmetz, N. F., & Evans, D. J. (2013). CPMV-DOX delivers. Molecular pharmaceutics, 10(1), 3-10.

Journal Article Type Article
Acceptance Date Jul 24, 2012
Online Publication Date Aug 6, 2012
Publication Date Jan 7, 2013
Deposit Date Nov 13, 2014
Journal Molecular Pharmaceutics
Print ISSN 1543-8384
Electronic ISSN 1543-8392
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 10
Issue 1
Pages 3-10
Keywords Cowpea mosaic virus; Doxorubicin; Drug-delivery
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