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Gut memories : towards a cognitive neurobiology of irritable bowel syndrome

Kennedy, Paul J.; Clarke, Gerard; Quigley, Eamonn M. M.; Groeger, John A.; Dinan, Timothy G.; Cryan, John F.

Authors

Paul J. Kennedy

Gerard Clarke

Eamonn M. M. Quigley

John A. Groeger

Timothy G. Dinan

John F. Cryan



Abstract

The brain and the gut are engaged in continual crosstalk along a number of pathways collectively termed the ‘brain–gut axis’. Over recent years it has become increasingly clear that dysregulation of the axis at a number of levels can result in disorders such as irritable bowel syndrome (IBS). With recent advances in neuroimaging technologies, insights into the neurobiology of IBS are beginning to emerge. However the cognitive neurobiology of IBS has remained relatively unexplored to date. In this review we summarise the available data on cognitive function in IBS. Moreover, we specifically address three key pathophysiological factors, namely; stress, immune activation and chronic pain, together with other factors involved in the manifestation of IBS, and explore how each of these components may impact centrally, what neurobiological mechanisms might be involved, and consider the implications for cognitive functioning in IBS. We conclude that each factor addressed could significantly impinge on central nervous system function, supporting the view that future research efforts must be directed towards a detailed assessment of cognitive function in IBS.

Citation

Kennedy, P. J., Clarke, G., Quigley, E. M. M., Groeger, J. A., Dinan, T. G., & Cryan, J. F. (2012). Gut memories : towards a cognitive neurobiology of irritable bowel syndrome. Neuroscience and Biobehavioral Reviews, 36(1), 310-340. https://doi.org/10.1016/j.neubiorev.2011.07.001

Journal Article Type Review
Acceptance Date Jul 4, 2011
Online Publication Date Jul 13, 2011
Publication Date 2012-01
Deposit Date Nov 13, 2014
Journal Neuroscience And Biobehavioral Reviews
Print ISSN 0149-7634
Electronic ISSN 1873-7528
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 36
Issue 1
Pages 310-340
DOI https://doi.org/10.1016/j.neubiorev.2011.07.001
Keywords Irritable bowel syndrome; IBS; Brain-gut axis; Cognition; Neurobiology; Neuropsychological; Central nervous system; Stress; Immune activity; Pain; Mood disorder; Sleep disturbance; Microbiota; Menstrual cycle; fMRI; PET
Public URL https://hull-repository.worktribe.com/output/467208
Publisher URL https://www.sciencedirect.com/science/article/pii/S0149763411001369?via%3Dihub