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Genomic analysis of companion rabbit Staphylococcus aureus

Holmes, Mark A.; Harrison, Ewan M.; Fisher, Elizabeth A.; Graham, Elizabeth M.; Parkhill, Julian; Foster, Geoffrey; Paterson, Gavin K.

Authors

Mark A. Holmes

Ewan M. Harrison

Elizabeth A. Fisher

Elizabeth M. Graham

Julian Parkhill

Geoffrey Foster

Gavin K. Paterson



Contributors

Axel Cloeckaert
Editor

Abstract

© 2016 Holmes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In addition to being an important human pathogen, Staphylococcus aureus is able to cause a variety of infections in numerous other host species. While the S. aureus strains causing infection in several of these hosts have been well characterised, this is not the case for companion rabbits (Oryctolagus cuniculus), where little data are available on S. aureus strains from this host. To address this deficiency we have performed antimicrobial susceptibility testing and genome sequencing on a collection of S. aureus isolates from companion rabbits. The findings show a diverse S. aureus population is able to cause infection in this host, and while antimicrobial resistance was uncommon, the isolates possess a range of known and putative virulence factors consistent with a diverse clinical presentation in companion rabbits including severe abscesses. We additionally show that companion rabbit isolates carry polymorphisms within dltB as described as underlying host-adaption of S. aureus to farmed rabbits. The availability of S. aureus genome sequences from companion rabbits provides an important aid to understanding the pathogenesis of dise ase in this host and in the clinical management and surveillance of these infections.

Journal Article Type Article
Publication Date Mar 1, 2016
Journal PLoS ONE
Print ISSN 1932-6203
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 11
Issue 3
Article Number ARTN e0151458
Pages e0151458
Institution Citation Holmes, M. A., Harrison, E. M., Fisher, E. A., Graham, E. M., Parkhill, J., Foster, G., & Paterson, G. K. (2016). Genomic analysis of companion rabbit Staphylococcus aureus. PloS one, 11(3), e0151458. doi:10.1371/journal.pone.0151458
DOI https://doi.org/10.1371/journal.pone.0151458
Keywords Staphylococcus aureus, Rabbits, Abscesses, Antimicrobial resistance
Publisher URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151458
Copyright Statement © 2016 Holmes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Additional Information Copy of article first published in: PLoS ONE, 20116, v.11, issue 3.

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Copyright Statement
© 2016 Holmes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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