Utilizing the metal coordination and supramolecular chemistry of macrocycles to tackle medicinal issues

Redshaw, Carl

Abstract

In this review, recent (post-2018) prominent examples of metal coordination and/or supramolecular chemistry of macrocycles, which have been employed against a variety of diseases are highlighted. The broad range of macrocycles available as well as their facile modification and, in some cases, the ability to act as hosts is leading to a growth in the use of macrocyclic metal-based agents against a number of common health issues as well as some of the lesser-known ailments. The focus here is mostly on the use of systems comprised of either calixarenes or cucurbiturils, but we also note some of the highlights that have emerged from the use of other metal-containing macrocyclic systems such as those based on pillarenes, cyclodextrins, crown ethers, and Schiff-base macrocycles. Much of the work is centered around improving the delivery and effectiveness of metal-containing anti-cancer drugs, particularly those based on platinum, however, there have also been advances in a number of other areas such as their use as agents against bacteria, TB or HIV. A significant body of work has also been conducted in conjunction with nanoparticles, where the surface of the nanoparticles has been modified with a view to subsequent use in medicine.

Citation

Redshaw, C. (2025). Utilizing the metal coordination and supramolecular chemistry of macrocycles to tackle medicinal issues. Coordination chemistry reviews, 523(pt.1), Article 216147. https://doi.org/10.1016/j.ccr.2024.216147

• Journal Article Type: Review
• Acceptance Date: Aug 7, 2024
• Online Publication Date: Oct 11, 2024
• Publication Date: Jan 15, 2025
• Deposit Date: Oct 18, 2024
• Publicly Available Date: Oct 21, 2024
• Journal: Coordination Chemistry Reviews
• Print ISSN: 0010-8545
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 523
• Issue: pt.1
• Article Number: 216147
• DOI: https://doi.org/10.1016/j.ccr.2024.216147
• Keywords: Macrocycle; Metal; Health; Calixarene; Cucurbituril; Pillarene; Cyclodextrin; Schiff-base
• Public URL: https://hull-repository.worktribe.com/output/4868604