The role of estrogen in cutaneous ageing and repair

Wilkinson, Holly N.; Hardman, Matthew J.

Abstract

© 2017 Elsevier B.V. Combined advances in modern medical practice and increased human longevity are driving an ever-expanding elderly population. Females are particularly at risk of age-associated pathology, spending more of their lives in a post-menopausal state. Menopause, denoted by a rapid decline in serum sex steroid levels, accelerates biological ageing across the body's tissues. Post-menopause physiological changes are particularly noticeable in the skin, which loses structural architecture and becomes prone to damage. The sex steroid most widely discussed as an intrinsic contributor to skin ageing and pathological healing is 17β-estradiol (or estrogen), although many others are involved. Estrogen deficiency is detrimental to many wound-healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment widely reverses these effects. Over recent decades, many of the molecular and cellular correlates to estrogen's beneficial effect on normal skin homeostasis and wound healing have been reported. However, disparities still exist, particularly in the context of mechanistic studies investigating estrogen receptor signalling and its potential cellular effects. New molecular techniques, coupled with increased understanding of estrogen in skin biology, will provide further opportunities to develop estrogen receptor-targeted therapeutics.

Citation

Wilkinson, H. N., & Hardman, M. J. (2017). The role of estrogen in cutaneous ageing and repair. Maturitas, 103, 60-64. https://doi.org/10.1016/j.maturitas.2017.06.026

• Acceptance Date: Jun 22, 2017
• Online Publication Date: Jun 23, 2017
• Publication Date: Sep 1, 2017
• Deposit Date: Dec 10, 2017
• Publicly Available Date: Dec 11, 2017
• Journal: Maturitas
• Print ISSN: 0378-5122
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 103
• Pages: 60-64
• DOI: https://doi.org/10.1016/j.maturitas.2017.06.026
• Keywords: Obstetrics and Gynaecology; General Biochemistry, Genetics and Molecular Biology
• Public URL: https://hull-repository.worktribe.com/output/499041
• Additional Information: This article is maintained by: Elsevier; Article Title: The role of estrogen in cutaneous ageing and repair; Journal Title: Maturitas; CrossRef DOI link to publisher maintained version: http://dx.doi.org/10.1016/j.maturitas.2017.06.026; Content Type: article; Copyright: © 2017 Elsevier B.V. All rights reserved.
• Contract Date: Dec 10, 2017