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Community IntraVenous Antibiotic Study (CIVAS): protocol for an evaluation of patient preferences for and cost-effectiveness of community intravenous antibiotic services

Czoski Murray, C; Twiddy, M; Meads, D; Hess, S; Wright, J; Mitchell, E D; Hulme, C; Dodd, S; Gent, H; Gregson, A; McLintock, K; Raynor, D K; Reynard, K; Stanley, P; Vincent, R; Minton, J

Authors

C Czoski Murray

D Meads

S Hess

J Wright

E D Mitchell

C Hulme

S Dodd

H Gent

A Gregson

K McLintock

D K Raynor

K Reynard

P Stanley

R Vincent

J Minton



Abstract

Introduction: Outpatient parenteral antimicrobial therapy (OPAT) is used to treat a wide range of infections, and is common practice in countries such as the USA and Australia. In the UK, national guidelines (standards of care) for OPAT services have been developed to act as a benchmark for clinical monitoring and quality. However, the availability of OPAT services in the UK is still patchy and until quite recently was available only in specialist centres. Over time, National Health Service (NHS) Trusts have developed OPAT services in response to local needs, which has resulted in different service configurations and models of care. However, there has been no robust examination comparing the cost-effectiveness of each service type, or any systematic examination of patient preferences for services on which to base any business case decision. Methods and analysis: The study will use a mixed methods approach, to evaluate patient preferences for and the cost-effectiveness of OPAT service models. The study includes seven NHS Trusts located in four counties. There are five inter-related work packages: a systematic review of the published research on the safety, efficacy and cost-effectiveness of intravenous antibiotic delivery services; a qualitative study to explore existing OPAT services and perceived barriers to future development; an economic model to estimate the comparative value of four different community intravenous antibiotic services; a discrete choice experiment to assess patient preferences for services, and an expert panel to agree which service models may constitute the optimal service model(s) of community intravenous antibiotics delivery. Ethics and dissemination: The study has been approved by the NRES Committee, South West-Frenchay using the Proportionate Review Service (ref 13/SW/0060). The results of the study will be disseminated at national and international conferences, and in international journals.

Citation

Czoski Murray, C., Twiddy, M., Meads, D., Hess, S., Wright, J., Mitchell, E. D., …Minton, J. (2015). Community IntraVenous Antibiotic Study (CIVAS): protocol for an evaluation of patient preferences for and cost-effectiveness of community intravenous antibiotic services. BMJ open, 5(8), Article e008965. https://doi.org/10.1136/bmjopen-2015-008965

Journal Article Type Article
Acceptance Date Jul 27, 2015
Online Publication Date Aug 21, 2015
Publication Date 2015-08
Deposit Date Dec 11, 2017
Publicly Available Date Mar 29, 2024
Journal BMJ Open
Print ISSN 2044-6055
Electronic ISSN 2044-6055
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 5
Issue 8
Article Number e008965
DOI https://doi.org/10.1136/bmjopen-2015-008965
Keywords General Medicine
Public URL https://hull-repository.worktribe.com/output/499638
Publisher URL http://bmjopen.bmj.com/content/5/8/e008965

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Copyright Statement
This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/





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