Lee Ingle
Prognostic value of the 6 min walk test and self-perceived symptom severity in older patients with chronic heart failure
Ingle, Lee; Rigby, Alan S.; Carroll, Sean; Butterly, Ron; King, Rod F.; Cooke, Carlton B.; Cleland, John G.J.F.; Clark, Andrew L.
Authors
Alan S. Rigby
Sean Carroll
Ron Butterly
Rod F. King
Carlton B. Cooke
John G.J.F. Cleland
Andrew L. Clark
Abstract
Background: The 6 min walk test (6-MWT) is a simple and popular test for evaluating functional status in patients with chronic heart failure (CHF). However, the prognostic value of the 6-MWT in a large, representative sample of CHF patients, and in patients with different degrees of left ventricular systolic dysfunction (LVSD) remains unclear. Methods and results: Of an initial population of 1592 patients, 212 died representing a crude death rate of 13.3%. In surviving patients, the median time to follow-up period was 36.6 months [inter-quartile range (IQR) 28-45 months]. Five variables remained independent predictors of all-cause mortality; decreasing 6-MWT distance, self-perceived signs of breathlessness at night (SOBAN), beta-blocker usage, elevated log NT-proBNP, and reduced haemoglobin concentration. We also dichotomized our analysis by LVSD status (≤mild LVSD or > mild LVSD). For patients with > mild LVSD, 6-MWT remained an important prognostic indicator but not in patients with ≤mild LVSD. Conclusion: The 6-MWT is an important independent predictor of mortality in CHF patients, and this was especially evident in patients with > mild LVSD. The 6-MWT provides little prognostic utility in patients with ≤mild LVSD. While log NT-proBNP was the most potent independent predictor, an additive prognostic effect was evident with the additional selection of 6-MWT. Patients' self-perceived symptoms, especially SOBAN was an independent predictor of mortality in our patients. © The European Society of Cardiology 2007. All rights reserved.
Citation
Ingle, L., Rigby, A. S., Carroll, S., Butterly, R., King, R. F., Cooke, C. B., Cleland, J. G., & Clark, A. L. (2007). Prognostic value of the 6 min walk test and self-perceived symptom severity in older patients with chronic heart failure. European Heart Journal, 28(5), 560-568. https://doi.org/10.1093/eurheartj/ehl527
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 17, 2007 |
Online Publication Date | Feb 21, 2007 |
Publication Date | 2007-03 |
Deposit Date | May 7, 2019 |
Journal | European Heart Journal |
Print ISSN | 0195-668X |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 28 |
Issue | 5 |
Pages | 560-568 |
DOI | https://doi.org/10.1093/eurheartj/ehl527 |
Keywords | Chronic heart failure; Exercise; Prognosis; Survival |
Public URL | https://hull-repository.worktribe.com/output/527356 |
Publisher URL | https://academic.oup.com/eurheartj/article/28/5/560/2887708 |
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