Optimization of the mechanical properties of calcium phosphate/multi-walled carbon nanotubes/bovine serum albumin composites using response surface methodology

Low, Kah Ling; Tan, Soon Huat; Zein, Sharif Hussein Sharif; McPhail, David S.; Boccaccini, Aldo R.

Abstract

Response surface methodology (RSM) coupled with the central composite design (CCD) was used to optimize the mechanical properties of calcium phosphate cement/multi-walled carbon nanotubes/bovine serum albumin (CPC/MWCNTs/BSA) composites. In this study, CPC composites were reinforced by multi-walled carbon nanotubes (MWCNTs) and bovine serum albumin (BSA) in order to induce high mechanical properties in the CPC/MWCNTs/BSA system. The effect of various process parameters on the compressive strength of CPC/MWCNTs/BSA composites was studied using design of experiments (DOE). The process parameters studied were: wt.% of MWCNTs (0.2-0.5 wt.%), wt.% of BSA (5-15. wt.%) and type of MWCNTs (e.g. as-pristine MWCNT (MWCNT-AP), hydroxyl group functionalized MWCNT (MWCNT-OH) and carboxyl group functionalized MWCNT (MWCNT-COOH)). Based on the CCD, a quadratic model was obtained to correlate the process parameters to the compressive strength of CPC/MWCNTs/BSA composites. From the analysis of variance (ANOVA), the most significant factor affected on the experimental design response was identified. The predicted compressive strength after process optimization was found to agree well with the experimental value. The results revealed that at 0.5. wt.% of MWCNT-OH and 15. wt.% of BSA, the highest compressive strength of 14. MPa was obtained. © 2011 Elsevier Ltd.

Citation

Low, K. L., Tan, S. H., Zein, S. H. S., McPhail, D. S., & Boccaccini, A. R. (2011). Optimization of the mechanical properties of calcium phosphate/multi-walled carbon nanotubes/bovine serum albumin composites using response surface methodology. Materials and Design, 32(6), 3312-3319. https://doi.org/10.1016/j.matdes.2011.02.022

• Journal Article Type: Article
• Acceptance Date: Feb 8, 2011
• Online Publication Date: Feb 12, 2011
• Publication Date: 2011-06
• Deposit Date: Jul 7, 2020
• Journal: Materials and Design
• Print ISSN: 0261-3069
• Electronic ISSN: 0264-1275
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 32
• Issue: 6
• Pages: 3312-3319
• DOI: https://doi.org/10.1016/j.matdes.2011.02.022
• Keywords: Composites; Mechanical; Scanning electron microscopy
• Public URL: https://hull-repository.worktribe.com/output/549923
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0261306911001002?via%3Dihub