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Morphological and Mechanical Biomimetic Bone Structures

Parwani, R.; Curto, M.; Kao, A. P.; Rowley, P. J.; Pani, M.; Tozzi, G.; Barber, A. H.

Authors

R. Parwani

M. Curto

A. P. Kao

P. J. Rowley

M. Pani

G. Tozzi

A. H. Barber



Abstract

Cortical bone is an example of a mineralized tissue containing a compositional distribution of hard and soft phases in 3-dimensional space for mechanical function. X-ray computed tomography (XCT) is able to describe this compositional and morphological complexity but methods to provide a physical output with comparable mechanical function is lacking. A workflow is presented here to establish a method of using high contrast XCT to establish a virtual model of cortical bone that is manufactured using a multiple material capable 3D printer. Resultant 3D printed structures were produced based on more and less remodelled bone designs exhibiting a range of secondary osteon density. Variation in resultant mechanical properties of the 3D printed composite structures for each bone design was achieved using a combination of material components and reasonable prediction of elastic modulus provided using a Hashin-Shtrikman approach. The ability to 3D print composite structures using high contrast XCT to distinguish between compositional phases in a biological structure promises improved anatomical models as well as next-generation mechano-mimetic implants.

Citation

Parwani, R., Curto, M., Kao, A. P., Rowley, P. J., Pani, M., Tozzi, G., & Barber, A. H. (2017). Morphological and Mechanical Biomimetic Bone Structures. ACS Biomaterials Science and Engineering, 3(11), 2761-2767. https://doi.org/10.1021/acsbiomaterials.6b00652

Journal Article Type Article
Acceptance Date Dec 19, 2016
Online Publication Date Dec 19, 2016
Publication Date Nov 13, 2017
Deposit Date Jan 25, 2018
Publicly Available Date Mar 28, 2024
Journal ACS Biomaterials Science and Engineering
Print ISSN 2373-9878
Electronic ISSN 2373-9878
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 3
Issue 11
Pages 2761-2767
DOI https://doi.org/10.1021/acsbiomaterials.6b00652
Public URL https://hull-repository.worktribe.com/output/557647
Publisher URL http://pubs.acs.org/doi/10.1021/acsbiomaterials.6b00652
Related Public URLs https://researchportal.port.ac.uk/portal/en/publications/morphological-and-mechanical-biomimetic-bone-structures(83d0ef45-0ace-4cb9-bcd6-44a1164f0296).html

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