Morphological and Mechanical Biomimetic Bone Structures

Parwani, R.; Curto, M.; Kao, A. P.; Rowley, P. J.; Pani, M.; Tozzi, G.; Barber, A. H.

Abstract

Cortical bone is an example of a mineralized tissue containing a compositional distribution of hard and soft phases in 3-dimensional space for mechanical function. X-ray computed tomography (XCT) is able to describe this compositional and morphological complexity but methods to provide a physical output with comparable mechanical function is lacking. A workflow is presented here to establish a method of using high contrast XCT to establish a virtual model of cortical bone that is manufactured using a multiple material capable 3D printer. Resultant 3D printed structures were produced based on more and less remodelled bone designs exhibiting a range of secondary osteon density. Variation in resultant mechanical properties of the 3D printed composite structures for each bone design was achieved using a combination of material components and reasonable prediction of elastic modulus provided using a Hashin-Shtrikman approach. The ability to 3D print composite structures using high contrast XCT to distinguish between compositional phases in a biological structure promises improved anatomical models as well as next-generation mechano-mimetic implants.

Citation

Parwani, R., Curto, M., Kao, A. P., Rowley, P. J., Pani, M., Tozzi, G., & Barber, A. H. (2017). Morphological and Mechanical Biomimetic Bone Structures. ACS Biomaterials Science and Engineering, 3(11), 2761-2767. https://doi.org/10.1021/acsbiomaterials.6b00652

• Journal Article Type: Article
• Acceptance Date: Dec 19, 2016
• Online Publication Date: Dec 19, 2016
• Publication Date: Nov 13, 2017
• Deposit Date: Jan 25, 2018
• Publicly Available Date: Jan 26, 2018
• Journal: ACS Biomaterials Science and Engineering
• Print ISSN: 2373-9878
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 11
• Pages: 2761-2767
• DOI: https://doi.org/10.1021/acsbiomaterials.6b00652
• Public URL: https://hull-repository.worktribe.com/output/557647
• Publisher URL: http://pubs.acs.org/doi/10.1021/acsbiomaterials.6b00652
• Related Public URLs: https://researchportal.port.ac.uk/portal/en/publications/morphological-and-mechanical-biomimetic-bone-structures(83d0ef45-0ace-4cb9-bcd6-44a1164f0296).html
• Contract Date: Jan 25, 2018