Salivary and serum androgens with anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome

Sathyapalan, Thozhukat; Al-Qaissi, Ahmed; Kilpatrick, Eric S.; Dargham, Soha R.; Keevil, Brian; Atkin, Stephen L.

Abstract

To determine the predictive value of a raised androgen level with an elevated anti-Müllerian hormone (AMH) for the diagnosis or exclusion of polycystic ovary syndrome (PCOS), a prospective cross-sectional study of 170 women (105 with PCOS type A and 65 normal) was undertaken. AMH was combined with one of, total serum testosterone (T); calculated free androgen index; salivary testosterone (salT); serum androstenedione (A); salivary androstenedione (salA). The diagnostic sensitivity and specificity of AMH (>35 pmol/l) alone for PCOS were 55% and 79% respectively. The diagnostic sensitivity and specificity of AMH (>35 pmol/l) with either an elevated T or raised FAI level for PCOS showed 100% specificity and a 100% positive predictive value. Conversely, diagnostic exclusion of PCOS was shown by an AMH

Citation

Sathyapalan, T., Al-Qaissi, A., Kilpatrick, E. S., Dargham, S. R., Keevil, B., & Atkin, S. L. (2018). Salivary and serum androgens with anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome. Scientific reports, 8(1), Article 3795. https://doi.org/10.1038/s41598-018-22176-1

• Journal Article Type: Article
• Acceptance Date: Feb 14, 2018
• Online Publication Date: Feb 28, 2018
• Publication Date: Dec 1, 2018
• Deposit Date: May 6, 2018
• Publicly Available Date: Oct 27, 2022
• Print ISSN: 2045-2322
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Issue: 1
• Article Number: 3795
• DOI: https://doi.org/10.1038/s41598-018-22176-1
• Keywords: Biomarkers; Endocrine reproductive disorders
• Public URL: https://hull-repository.worktribe.com/output/618129
• Publisher URL: https://www.nature.com/articles/s41598-018-22176-1
• Contract Date: May 10, 2018