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The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects

Al-Qaissi, Ahmed; Alqarni, Saeed; Javed, Zeeshan; Atkin, Stephen L.; Sathyapalan, Thozhukat; Vince, Rebecca; Madden, Leigh A.


Ahmed Al-Qaissi

Saeed Alqarni

Zeeshan Javed

Stephen L. Atkin


© 2019, The Author(s). Background: A retrospective analysis was carried out from patients and controls during the past 5 years from a series of studies investigating endothelial microparticles (MP). Methods: In total, 319 samples from 207 individuals were included in this analysis, from patients with type 2 diabetes (T2D, n = 105), women with polycystic ovary syndrome (PCOS, n = 145) and healthy volunteers (n = 69). All data were generated via the same flow cytometry protocol with the same antibody clones. Endothelial markers CD105 (Endoglin) and CD106 (Vascular cell adhesion molecule-1) were used to enumerate MP in venous blood. Results: The ratio of CD105MP:CD106MP was significantly different between groups (F = 63.43, p < 0.0001). Women with PCOS were found to have a median CD105MP:CD106MP ratio of 0.40 (IQR 0.24–0.57), suggesting approximately two CD106MP were found per CD105MP. The T2D group showed a median ratio of 2.32 (1.51–3.69) whereas in healthy volunteers the ratio was 2.21 (1.63–3.55). Serum intercellular adhesion molecule-1 was also shown to be significantly increased in PCOS when compared with control or T2D groups (F = 14.5, p < 0.001). Conclusion: These data suggest that women with PCOS have an altered endothelial MP release in favour of CD106. Thus a potential activated endothelial state exists in women with PCOS with a shift towards a predominantly CD106MP profile.


Al-Qaissi, A., Alqarni, S., Javed, Z., Atkin, S. L., Sathyapalan, T., Vince, R., & Madden, L. A. (2019). The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects. Endocrine,

Journal Article Type Article
Acceptance Date Aug 12, 2019
Online Publication Date Aug 27, 2019
Publication Date Aug 27, 2019
Deposit Date Aug 31, 2019
Publicly Available Date Oct 27, 2022
Journal Endocrine
Print ISSN 1355-008X
Electronic ISSN 1559-0100
Publisher Springer (part of Springer Nature)
Peer Reviewed Peer Reviewed
Keywords Polycystic ovary syndrome; Endothelial microparticles; VCAM-1
Public URL
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Article (678 Kb)

Copyright Statement
© The Author(s) 2019<br /> Open Access<br /> This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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