Skip to main content

Research Repository

Advanced Search

Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

Savoie, Huguette; Figliola, Carlotta; Marchal, Estelle; Crabbe, Bry W.; Hallett-Tapley, Geniece L.; Boyle, Ross W.; Thompson, Alison


Huguette Savoie

Carlotta Figliola

Estelle Marchal

Bry W. Crabbe

Geniece L. Hallett-Tapley

Alison Thompson


© 2018 The Royal Society of Chemistry and Owner Societies. The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). A comparison of incubation and irradiation frameworks for the three prodigiosenes is reported, with activity against ER- and ER+ lines explored. Furthermore, the ability of the three prodigiosenes to photosensitise the production of singlet oxygen is demonstrated, shedding mechanistic light onto possible photodynamic therapeutic effects of this class of tripyrroles.


Savoie, H., Figliola, C., Marchal, E., Crabbe, B. W., Hallett-Tapley, G. L., Boyle, R. W., & Thompson, A. (2018). Photo-induced anticancer activity and singlet oxygen production of prodigiosenes. Photochemical & photobiological sciences : an international journal, 17(5), 599-606.

Journal Article Type Article
Acceptance Date Mar 30, 2018
Online Publication Date Apr 12, 2018
Publication Date Apr 12, 2018
Deposit Date Jun 4, 2018
Publicly Available Date Apr 13, 2019
Journal Photochemical & Photobiological Sciences
Print ISSN 1474-905X
Electronic ISSN 1474-9092
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 17
Issue 5
Pages 599-606
Keywords Physical and Theoretical Chemistry
Public URL
Additional Information : This document is Similarity Check deposited; : Supplementary Information; : Geniece L. Hallett-Tapley (ORCID); : Ross W. Boyle (ORCID); : Alison Thompson (ORCID); : Single-blind; : Received 8 February 2018; Accepted 30 March 2018; Advance Article published 12 April 2018


You might also like

Downloadable Citations