Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

Savoie, Huguette; Figliola, Carlotta; Marchal, Estelle; Crabbe, Bry W.; Hallett-Tapley, Geniece L.; Boyle, Ross W.; Thompson, Alison

Abstract

© 2018 The Royal Society of Chemistry and Owner Societies. The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). A comparison of incubation and irradiation frameworks for the three prodigiosenes is reported, with activity against ER- and ER+ lines explored. Furthermore, the ability of the three prodigiosenes to photosensitise the production of singlet oxygen is demonstrated, shedding mechanistic light onto possible photodynamic therapeutic effects of this class of tripyrroles.

Citation

Savoie, H., Figliola, C., Marchal, E., Crabbe, B. W., Hallett-Tapley, G. L., Boyle, R. W., & Thompson, A. (2018). Photo-induced anticancer activity and singlet oxygen production of prodigiosenes. Photochemical & photobiological sciences : an international journal, 17(5), 599-606. https://doi.org/10.1039/c8pp00060c

• Journal Article Type: Article
• Acceptance Date: Mar 30, 2018
• Online Publication Date: Apr 12, 2018
• Publication Date: Apr 12, 2018
• Deposit Date: Jun 4, 2018
• Publicly Available Date: Apr 13, 2019
• Journal: Photochemical & Photobiological Sciences
• Print ISSN: 1474-905X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 5
• Pages: 599-606
• DOI: https://doi.org/10.1039/c8pp00060c
• Keywords: Physical and Theoretical Chemistry
• Public URL: https://hull-repository.worktribe.com/output/816904
• Additional Information: : This document is Similarity Check deposited; : Supplementary Information; : Geniece L. Hallett-Tapley (ORCID); : Ross W. Boyle (ORCID); : Alison Thompson (ORCID); : Single-blind; : Received 8 February 2018; Accepted 30 March 2018; Advance Article published 12 April 2018
• Contract Date: Jun 5, 2018