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Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

Savoie, Huguette; Figliola, Carlotta; Marchal, Estelle; Crabbe, Bry W.; Hallett-Tapley, Geniece L.; Boyle, Ross W.; Thompson, Alison

Authors

Huguette Savoie

Carlotta Figliola

Estelle Marchal

Bry W. Crabbe

Geniece L. Hallett-Tapley

Alison Thompson



Abstract

© 2018 The Royal Society of Chemistry and Owner Societies. The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). A comparison of incubation and irradiation frameworks for the three prodigiosenes is reported, with activity against ER- and ER+ lines explored. Furthermore, the ability of the three prodigiosenes to photosensitise the production of singlet oxygen is demonstrated, shedding mechanistic light onto possible photodynamic therapeutic effects of this class of tripyrroles.

Journal Article Type Article
Publication Date Apr 12, 2018
Journal Photochemical & Photobiological Sciences
Print ISSN 1474-905X
Electronic ISSN 1474-9092
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 17
Issue 5
Pages 599-606
Institution Citation Savoie, H., Figliola, C., Marchal, E., Crabbe, B. W., Hallett-Tapley, G. L., Boyle, R. W., & Thompson, A. (2018). Photo-induced anticancer activity and singlet oxygen production of prodigiosenes. Photochemical & photobiological sciences : an international journal, 17(5), 599-606. https://doi.org/10.1039/c8pp00060c
DOI https://doi.org/10.1039/c8pp00060c
Keywords Physical and Theoretical Chemistry
Copyright Statement ©2018 University of Hull
Additional Information : This document is Similarity Check deposited; : Supplementary Information; : Geniece L. Hallett-Tapley (ORCID); : Ross W. Boyle (ORCID); : Alison Thompson (ORCID); : Single-blind; : Received 8 February 2018; Accepted 30 March 2018; Advance Article published 12 April 2018

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