Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

Savoie, Huguette; Figliola, Carlotta; Marchal, Estelle; Crabbe, Bry W.; Hallett-Tapley, Geniece L.; Boyle, Ross W.; Thompson, Alison

doi:10.1039/c8pp00060c

Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

Savoie, Huguette; Figliola, Carlotta; Marchal, Estelle; Crabbe, Bry W.; Hallett-Tapley, Geniece L.; Boyle, Ross W.; Thompson, Alison

Authors

Huguette Savoie

Carlotta Figliola

Estelle Marchal

Bry W. Crabbe

Geniece L. Hallett-Tapley

Professor Ross Boyle R.W.Boyle@hull.ac.uk
Professor of Biological Chemistry

Alison Thompson

Abstract

© 2018 The Royal Society of Chemistry and Owner Societies. The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). A comparison of incubation and irradiation frameworks for the three prodigiosenes is reported, with activity against ER- and ER+ lines explored. Furthermore, the ability of the three prodigiosenes to photosensitise the production of singlet oxygen is demonstrated, shedding mechanistic light onto possible photodynamic therapeutic effects of this class of tripyrroles.

Citation

Savoie, H., Figliola, C., Marchal, E., Crabbe, B. W., Hallett-Tapley, G. L., Boyle, R. W., & Thompson, A. (2018). Photo-induced anticancer activity and singlet oxygen production of prodigiosenes. Photochemical & photobiological sciences : an international journal, 17(5), 599-606. https://doi.org/10.1039/c8pp00060c

Journal Article Type	Article
Acceptance Date	Mar 30, 2018
Online Publication Date	Apr 12, 2018
Publication Date	Apr 12, 2018
Deposit Date	Jun 4, 2018
Publicly Available Date	Apr 13, 2019
Journal	Photochemical & Photobiological Sciences
Print ISSN	1474-905X
Electronic ISSN	1474-9092
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	17
Issue	5
Pages	599-606
DOI	https://doi.org/10.1039/c8pp00060c
Keywords	Physical and Theoretical Chemistry
Public URL	https://hull-repository.worktribe.com/output/816904
Additional Information	: This document is Similarity Check deposited; : Supplementary Information; : Geniece L. Hallett-Tapley (ORCID); : Ross W. Boyle (ORCID); : Alison Thompson (ORCID); : Single-blind; : Received 8 February 2018; Accepted 30 March 2018; Advance Article published 12 April 2018