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Symptom prevalence of patients with fibrotic interstitial lung disease: A systematic literature review

Carvajalino, Sabrina; Reigada, Carla; Johnson, Miriam J.; Dzingina, Mendwas; Bajwah, Sabrina

Authors

Sabrina Carvajalino sabricarv@gmail.com

Carla Reigada

Mendwas Dzingina

Sabrina Bajwah



Abstract

© 2018 The Author(s). Background: Those affected by advanced fibrotic interstitial lung diseases have limited treatment options and in the terminal stages, the focus of care is on symptom management. However, quantitatively, little is known about symptom prevalence. We aimed to determine the prevalence of symptoms in Progressive Idiopathic Fibrotic Interstitial Lung Disease (PIF-ILD). Methods: Searches on eight electronic databases including MEDLINE for clinical studies between 1966 and 2015 where the target population was adults with PIF-ILD and for whom the prevalence of symptoms had been calculated. Results: A total of 4086 titles were screened for eligibility criteria; 23 studies were included for analysis. The highest prevalence was that for breathlessness (54-98%) and cough (59-100%) followed by heartburn (25-65%) and depression (10-49%). The heterogeneity of studies limited their comparability, but many of the symptoms present in patients with other end-stage disease were also seen in PIF-ILD. Conclusions: This is the first quantitative review of symptoms in people with Progressive Idiopathic Fibrotic Interstitial Lung Diseases. Symptoms are common, often multiple and have a comparable prevalence to those experienced in other advanced diseases. Quantification of these data provides valuable information to inform the allocation of resources.

Citation

Carvajalino, S., Reigada, C., Johnson, M. J., Dzingina, M., & Bajwah, S. (2018). Symptom prevalence of patients with fibrotic interstitial lung disease: A systematic literature review. BMC Pulmonary Medicine, 18(1), doi:10.1186/s12890-018-0651-3

Journal Article Type Article
Acceptance Date May 15, 2018
Online Publication Date May 22, 2018
Publication Date 2018-12
Deposit Date Jul 19, 2018
Publicly Available Date Jul 19, 2018
Electronic ISSN 1471-2466
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 18
Issue 1
Article Number 78
DOI https://doi.org/10.1186/s12890-018-0651-3
Keywords Pulmonary fibrosis; Symptom prevalence and interstitial lung disease
Public URL https://hull-repository.worktribe.com/output/855150
Publisher URL https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-018-0651-3
Copyright Statement © The Author(s). 2018
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Publisher Licence URL
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Copyright Statement
© The Author(s). 2018
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.


Article (1.4 Mb)
PDF

Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
© The Author(s). 2018
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.





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