Low serum chloride in patients with chronic heart failure: clinical associations and prognostic significance

Cuthbert, Joseph J.; Pellicori, Pierpaolo; Rigby, Alan; Pan, Daniel; Kazmi, Syed; Shah, Parin; Clark, Andrew L.

Abstract

© 2018 The Authors. European Journal of Heart Failure © 2018 European Society of Cardiology Background: Low serum chloride is common in patients with chronic heart failure (CHF) and is associated with worse outcomes. We investigated the clinical and prognostic associations, including cause of death associations, of low serum chloride in patients referred to a secondary care clinic with suspected heart failure. Methods and results: Patients with echocardiogram and serum chloride were evaluated (n = 5613). CHF was defined as signs and symptoms of the disease and either left ventricular systolic dysfunction (LVSD) worse than mild [heart failure with reduced ejection fraction (HFrEF)] or LVSD mild or better and raised amino-terminal pro-B-type natriuretic peptide (NT-proBNP) levels (>125 ng/L) [heart failure with preserved ejection fraction (HFpEF)]. Hypochloraemia was defined as greater than two standard deviations below the mean in the local normal distribution (

Citation

Cuthbert, J. J., Pellicori, P., Rigby, A., Pan, D., Kazmi, S., Shah, P., & Clark, A. L. (2018). Low serum chloride in patients with chronic heart failure: clinical associations and prognostic significance. European journal of heart failure, 20(10), 1426-1435. https://doi.org/10.1002/ejhf.1247

• Journal Article Type: Article
• Acceptance Date: May 23, 2018
• Online Publication Date: Jun 26, 2018
• Publication Date: Oct 10, 2018
• Deposit Date: Jul 3, 2018
• Publicly Available Date: Jun 27, 2019
• Print ISSN: 1388-9842
• Electronic ISSN: 1879-0844
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: 10
• Pages: 1426-1435
• DOI: https://doi.org/10.1002/ejhf.1247
• Keywords: Heart failure; Chloride; Outcome; Hypochloraemia; Diuretics; Prognosis
• Public URL: https://hull-repository.worktribe.com/output/907663
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/ejhf.1247