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The challenge of external validity in policy-relevant systematic reviews: A case study from the field of substance misuse

Pearson, Mark; Coomber, Ross


Ross Coomber


Aim  To critically evaluate the methods utilized in the conduct of a systematic review in the field of substance misuse

Design  Participant‐observation in the review process, semi‐structured interviews with review team members and management and structured observation of the process of guidance development.

Setting  An ‘arm's‐length’ government body.

Participants  Review team members, management and the committee responsible for producing evidence‐based guidance for policy and practice.

Measurements  Data from interviews and (participant‐)observation were reflected upon critically in order to increase understanding of the systematic review process.

Findings  The application of systematic review methods produced an evidence base that did not inform the development of guidance to the extent that it could have done: (i) an emphasis upon internal research validity produced an evidence base with an emphasis on short‐term interventions at the level of the individual; (ii) criteria for appraising the external validity of studies were not developed sufficiently; and (iii) the systematic review of evidence and development of guidance are strongly reliant upon the judgement of reviewers and committee members.

Conclusions  Prioritizing internal validity in a systematic review risks producing an evidence base that is not informed adequately by the wider determinants of health and which does not give sufficient consideration to external validity. The use of appropriate methods requires that commissioners of systematic reviews are clear at the outset how the review is proposed to be utilized. Review methods such as meta‐ethnography and realist synthesis could contribute to making the frameworks within which judgements are made more explicit.

Journal Article Type Review
Publication Date Jan 1, 2010
Journal Addiction
Print ISSN 0965-2140
Electronic ISSN 1360-0443
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 105
Issue 1
Pages 136-145
APA6 Citation Pearson, M., & Coomber, R. (2010). The challenge of external validity in policy-relevant systematic reviews: A case study from the field of substance misuse. Addiction, 105(1), 136-145. doi:10.1111/j.1360-0443.2009.02713.x
Keywords Environmental influences; Guidance development; Policy; Substance misuse in the young; Systematic review methods
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