Jaya Sujatha Gopal-Kothandapani
Effect of vitamin D supplementation on free and total vitamin D: A comparison of Asians and Caucasians
Gopal-Kothandapani, Jaya Sujatha; Evans, Lucy Faith; Walsh, Jennifer S.; Gossiel, Fatma; Rigby, Alan S.; Eastell, Richard; Bishop, Nick J.
Authors
Lucy Faith Evans
Jennifer S. Walsh
Fatma Gossiel
Alan S. Rigby
Richard Eastell
Nick J. Bishop
Abstract
Objectives
It is well established that UK Asians typically have lower vitamin D levels than Caucasians. It is also known that vitamin D binding protein (DBP) is lower in some races than Caucasians. To investigate how ethnicity, skin colour and genetic variation affect the response to vitamin D (15000 IU) administered to young Asian and Caucasian men.
Design
Prospective, single‐centre clinical trial.
Participants
Sixty young men (18‐25 year) of Asian (n = 30) and Caucasian (n = 30) origin.
Measurements
We measured serum calcium, phosphate, magnesium, alkaline phosphatase, albumin, parathyroid hormone; total 25 hydroxyvitamin D (25OHD); calculated and directly measured free 25OHD; DBP at baseline and 4 weeks; DBP genotype, skin colour (Fitzpatrick scale), dietary vitamin D and calcium intake at baseline; and urine calcium:creatinine ratio at baseline, 1 and 4 weeks.
Results
At baseline, Asians had lower serum total 25OHD (26.4 [13.7] vs 34.1 [12.3] nmol/L P = 0.0272) and DBP (6.7 [3.4] vs 9.6 [4.4] nmol/L; P = 0.0065) but similar free 25OHD (16.7 [10.4] vs 17.8 [7.5] pmol/L P = 0.6530). After dosing, total 25OHD rose similarly in each group (≈56 nmol/L), but measured free 25OHD rose more in Asians (18.1 [9.4] vs 12.2 [13.3] pmol/L P = 0.0464). Lower DBP at baseline, possibly reflecting genotype differences, was associated with a greater change in measured free 25OHD in Caucasians, but not in Asians.
Conclusions
Asian compared with Caucasian males had a larger increment in measured free 25OHD following 150 000 units vitamin D3, possibly reflecting differences in DBP affinity for 25OHD. Ethnicity should be considered when devising guidelines for the treatment of vitamin D deficiency.
Citation
Gopal-Kothandapani, J. S., Evans, L. F., Walsh, J. S., Gossiel, F., Rigby, A. S., Eastell, R., & Bishop, N. J. (2019). Effect of vitamin D supplementation on free and total vitamin D: A comparison of Asians and Caucasians. Clinical Endocrinology, 90(1), 222-231. https://doi.org/10.1111/cen.13825
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 30, 2018 |
Online Publication Date | Sep 9, 2018 |
Publication Date | Jan 1, 2019 |
Deposit Date | Aug 1, 2018 |
Publicly Available Date | Sep 10, 2019 |
Print ISSN | 0300-0664 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 90 |
Issue | 1 |
Pages | 222-231 |
DOI | https://doi.org/10.1111/cen.13825 |
Keywords | Bioavailable 25 hydroxy vitamin D; Ethnicity; Serum measured free 25 hydroxyvitamin D; Vitamin D binding protein; Vitamin D binding protein genotype; Vitamin D3 |
Public URL | https://hull-repository.worktribe.com/output/959268 |
Publisher URL | https://onlinelibrary.wiley.com/doi/full/10.1111/cen.13825 |
Contract Date | Aug 1, 2018 |
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©2019 The author
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