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All Outputs (226)

Azithromycin, Oesophageal Function, and Cough in Chronic Respiratory Disease (2025)
Thesis
Sykes, D. (2025). Azithromycin, Oesophageal Function, and Cough in Chronic Respiratory Disease. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/5287949

Chronic cough is a disabling feature of many chronic respiratory diseases and is now recognised as a distinct disease. Despite being amongst the commonest causes for healthcare contact, there are no licenced treatments for chronic cough in the UK. Th... Read More about Azithromycin, Oesophageal Function, and Cough in Chronic Respiratory Disease.

Camlipixant in Refractory Chronic Cough: A Phase 2b, Randomized, Placebo-controlled Trial (SOOTHE) (2025)
Journal Article
Smith, J. A., Birring, S. S., Blaiss, M. S., McGarvey, L., Morice, A. H., Sher, M., Carroll, K. J., Garin, M., Lanouette, S., Shaw, J., Yang, R., & Bonuccelli, C. M. (2025). Camlipixant in Refractory Chronic Cough: A Phase 2b, Randomized, Placebo-controlled Trial (SOOTHE). American Journal of Respiratory and Critical Care Medicine, 211(6), 1038-1048. https://doi.org/10.1164/rccm.202409-1752OC

Rationale: There is no broadly accessible treatment for patients with refractory chronic cough, a disease characterized by chronic cough that persists despite treatment for other cough-related etiologies or has no identified underlying cause. Objecti... Read More about Camlipixant in Refractory Chronic Cough: A Phase 2b, Randomized, Placebo-controlled Trial (SOOTHE).

Dextromethorphan versus Dextrorphan: A Quantitative Comparison of Antitussive Potency following Separate Administration of Metabolite (2025)
Journal Article
Rezaee, S., Wright, C. E., Morice, A. H., & Rostami-Hodjegan, A. (2025). Dextromethorphan versus Dextrorphan: A Quantitative Comparison of Antitussive Potency following Separate Administration of Metabolite. The Journal of Clinical Pharmacology, https://doi.org/10.1002/jcph.70049

To assess the antitussive effects of dextrorphan (DOR) relative to its parent compound, dextromethorphan (DEX) a double-blind, randomized, placebo-controlled crossover study was conducted in 23 healthy volunteers using citric acid cough challenge tes... Read More about Dextromethorphan versus Dextrorphan: A Quantitative Comparison of Antitussive Potency following Separate Administration of Metabolite.

Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment (2025)
Journal Article
Birring, S. S., Dicpinigaitis, P. V., Maher, T. M., Mazzone, S. B., Page, C. P., Hawi, A., Sciascia, T., & Morice, A. H. (2025). Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment. Lung, 203, Article 62. https://doi.org/10.1007/s00408-025-00812-8

Chronic cough is a significant burden on patient quality of life and is associated with poor health outcomes. Chronic cough may be a result of neural hypersensitivity due to changes in both the peripheral and the central nervous systems, although the... Read More about Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment.

Classification for long-term monitoring of cough. Case Study (2025)
Journal Article
den Brinker, A. C., Rietman, R., Ouweltjes, O., van Marion, M., Thackray-Nocera, S., Crooks, M. G., & Morice, A. H. (2025). Classification for long-term monitoring of cough. Case Study. Discover Artificial Intelligence, 5, Article 56. https://doi.org/10.1007/s44163-025-00264-2

For management of chronic respiratory diseases, unobtrusive longitudinal monitoring of cough has been proposed. Such a monitoring system was developed using a classifier trained on an initial observation period. After this initial period, a personali... Read More about Classification for long-term monitoring of cough. Case Study.

Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT (2025)
Journal Article
Devereux, G., Cotton, S., Nath, M., McMeekin, N., Campbell, K., Chaudhuri, R., Choudhury, G., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lee, A., MacLennan, G., Morice, A., Norrie, J., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J., …Lipworth, B. (2025). Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT. Health Technology Assessment, 29(17), 1-97. https://doi.org/10.3310/TNDG8641

Background: Observational studies of people with chronic obstructive pulmonary disease using beta-blockers for cardiovascular disease indicate that beta-blocker use is associated with reduced risk of chronic obstructive pulmonary disease exacerbation... Read More about Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT.

How Will a Treatable Traits Approach Reshape Clinical Practice in Chronic Cough? (2025)
Journal Article
Kim, Y., Birring, S. S., McGarvey, L., Morice, A. H., & Song, W. J. (2025). How Will a Treatable Traits Approach Reshape Clinical Practice in Chronic Cough?. Allergy Asthma and Immunology Research, 17(3), 304-316. https://doi.org/10.4168/aair.2025.17.3.304

Chronic cough, which affects 5%–18% of adults, has traditionally been considered a symptom defined by its duration. However, recent advances in understanding the pathophysiology of chronic cough have prompted the concept that chronic cough may exist... Read More about How Will a Treatable Traits Approach Reshape Clinical Practice in Chronic Cough?.

Unmet needs and future directions of treatment options for chronic cough (2025)
Journal Article
Zhang, M., & Morice, A. (2025). Unmet needs and future directions of treatment options for chronic cough. Expert Review of Respiratory Medicine, https://doi.org/10.1080/17476348.2025.2499663

Introduction: Chronic cough is a persistent condition that significantly affects patients’ quality of life and poses diagnostic and therapeutic challenges. Traditional anatomical diagnostic approaches often fail to address the underlying mechanisms,... Read More about Unmet needs and future directions of treatment options for chronic cough.

Camlipixant in Refractory Chronic Cough: A Phase 2a, Randomized Controlled Trial (RELIEF) (2025)
Journal Article
Smith, J. A., Morice, A. H., Birring, S. S., Parker, S. M., Marsden, P. A., Holcomb, J. R., Sher, M., Prenner, B. M., Steven, G., Carroll, K. J., Lanouette, S., Garceau, D., Harvey, L., & Bonuccelli, C. M. (2025). Camlipixant in Refractory Chronic Cough: A Phase 2a, Randomized Controlled Trial (RELIEF). American Journal of Respiratory and Critical Care Medicine, 211(6), 1072-1075. https://doi.org/10.1164/rccm.202501-0093RL

Cough frequency has a high daily variation in patients with chronic cough (2025)
Journal Article
Morice, A., Alge, M., Kuett, L., Hart, S., Rigby, A., & Elkayam, D. (2025). Cough frequency has a high daily variation in patients with chronic cough. ERJ Open Research, 11(1), Article 00670-2024. https://doi.org/10.1183/23120541.00670-2024

Opening paragraph:
Chronic cough (coughing lasting 8 weeks or longer) is a burdensome disease, causing low quality of life due to the disruption that frequent coughing causes to daily life. Its prevalence is estimated to be 10% of the global populat... Read More about Cough frequency has a high daily variation in patients with chronic cough.

Nighttime Cough Characteristics in Chronic Obstructive Pulmonary Disease Patients (2025)
Journal Article
den Brinker, A. C., Ouweltjes, O., Rietman, R., Thackray-Nocera, S., Crooks, M. G., & Morice, A. H. (2025). Nighttime Cough Characteristics in Chronic Obstructive Pulmonary Disease Patients. Sensors, 25(2), Article 404. https://doi.org/10.3390/s25020404

Coughing is a symptom of many respiratory diseases. An increased amount of coughs may signal an (upcoming) health issue, while a decreasing amount of coughs may indicate an improved health status. The presence of a cough can be identified by a cough... Read More about Nighttime Cough Characteristics in Chronic Obstructive Pulmonary Disease Patients.

Can Passive Cough Monitoring Predict COPD Exacerbations? (2025)
Journal Article
Morice, A. H., den Brinker, A. C., Crooks, M., Thackray-Nocera, S., Ouweltjes, O., & Rietman, R. (2025). Can Passive Cough Monitoring Predict COPD Exacerbations?. COPD: Journal of Chronic Obstructive Pulmonary Disease, 22(1), Article 2487909. https://doi.org/10.1080/15412555.2025.2487909

Purpose: Validation of an alert mechanism for COPD exacerbations based on coughing detected by a stationary unobtrusive nighttime monitor. Methods: This prospective double-blind longitudinal study of cough monitoring included 40 chronic obstructive p... Read More about Can Passive Cough Monitoring Predict COPD Exacerbations?.

Cough Reflex Hypersensitivity as a Key Treatable Trait (2024)
Journal Article
Song, W. J., Manian, D. V., Kim, Y., Zhang, M., & Morice, A. H. (in press). Cough Reflex Hypersensitivity as a Key Treatable Trait. The journal of allergy and clinical immunology. In practice, https://doi.org/10.1016/j.jaip.2024.10.046

Cough reflex hypersensitivity is emerging as a key treatable trait in chronic cough and other cough-associated respiratory conditions. This review examines the neurological basis of cough, highlighting the complex interplay between peripheral and cen... Read More about Cough Reflex Hypersensitivity as a Key Treatable Trait.

Current and emerging opioids for the treatment of chronic cough: a mini review (2024)
Journal Article
Zhang, M., & Morice, A. H. (online). Current and emerging opioids for the treatment of chronic cough: a mini review. Expert Opinion on Pharmacotherapy, https://doi.org/10.1080/14656566.2024.2418983

Introduction: Chronic cough has increasingly been recognized as a distinct clinical entity that affects a significant portion of the global population. Despite advancements in understanding its pathophysiology, treatment options remain limited. Opioi... Read More about Current and emerging opioids for the treatment of chronic cough: a mini review.

Practice review: Pharmacological management of severe chronic breathlessness in adults with advanced life-limiting diseases (2024)
Journal Article
Simon, S. T., Higginson, I. J., Bausewein, C., Jolley, C. J., Bajwah, S., Maddocks, M., Wilharm, C., Oluyase, A. O., & Pralong, A. (online). Practice review: Pharmacological management of severe chronic breathlessness in adults with advanced life-limiting diseases. Palliative medicine, https://doi.org/10.1177/02692163241270945

Background: Severe and refractory chronic breathlessness is a common and burdensome symptom in patients with advanced life-limiting disease. Its clinical management is challenging because of the lack of effective interventions. Aim: To provide practi... Read More about Practice review: Pharmacological management of severe chronic breathlessness in adults with advanced life-limiting diseases.

Decoding the impact of the placebo response in clinical trials for chronic cough (2024)
Journal Article
Zhang, M., Zhang, B., & Morice, A. H. (2024). Decoding the impact of the placebo response in clinical trials for chronic cough. ERJ Open Research, 10(5), Article 00335-2024. https://doi.org/10.1183/23120541.00335-2024

Chronic cough is a prevalent and challenging condition, with limited treatment options available. The interpretation of clinical trial results for antitussive drugs is complicated by the presence of the placebo response, which can confound outcomes a... Read More about Decoding the impact of the placebo response in clinical trials for chronic cough.

Correction to: Reducing short-acting beta-agonist use in asthma: Impact of national incentives on prescribing practices in England and the findings from SENTINEL Plus early adopter sites (npj Primary Care Respiratory Medicine, (2024), 34, 1, (6), 10.1038/s41533-024-00363-0) (2024)
Journal Article
Crooks, M. G., Cummings, H., Morice, A. H., Sykes, D., Brooks, S., Jackson, A., & Xu, Y. (2024). Correction to: Reducing short-acting beta-agonist use in asthma: Impact of national incentives on prescribing practices in England and the findings from SENTINEL Plus early adopter sites (npj Primary Care Respiratory Medicine, (2024), 34, 1, (6), 10.1038/s41533-024-00363-0). NPJ Primary Care Respiratory Medicine, 34(1), Article 19. https://doi.org/10.1038/s41533-024-00376-9

Correction to: npj Primary Care Respiratory Medicine34, 6 (2024) https://doi.org/10.1038/s41533-024-00363-0, published online 29 April 2024 In this article the Table 2 columns were incorrectly structured. The original article has been corrected.