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All Outputs (167)

Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy) (2019)
Journal Article
Sadofsky, L. R., Hayman, Y. A., Vance, J., Cervantes, J. L., Fraser, S. D., Wilkinson, H. N., …Morice, A. H. (2019). Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy). Lung, 197(6), 687-698. https://doi.org/10.1007/s00408-019-00288-3

Purpose: There is currently no true macrophage cell line and in vitro experiments requiring these cells currently require mitogenic stimulation of a macrophage precursor cell line (THP-1) or ex vivo maturation of circulating primary monocytes. In thi... Read More about Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy).

Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity? (2019)
Journal Article
Holden, S. E., Morice, A., Birring, S. S., Jenkins-Jones, S., Langerman, H., Weaver, J., & Currie, C. J. (2020). Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity?. Current Medical Research and Opinion, 36(1), 139-150. https://doi.org/10.1080/03007995.2019.1673716

© 2019 Informa UK Limited, trading as Taylor & Francis Group. Objective: To investigate patterns of presentation of cough in primary care and develop an algorithm to identify probable and possible chronic cough (CC). Methods: This retrospective obs... Read More about Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity?.

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children (2019)
Journal Article
Morice, A. H., Millqvist, E., Bieksiene, K., Birring, S. S., Dicpinigaitis, P., Ribas, C. D., …Zacharasiewicz, A. (2020). ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. European respiratory journal, 55(1), https://doi.org/10.1183/13993003.01136-2019

Copyright © ERS 2020 These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of patients to... Read More about ERS guidelines on the diagnosis and treatment of chronic cough in adults and children.

The effect of aclidinium on symptoms including cough in chronic obstructive pulmonary disease: A phase 4, double-blind, placebo-controlled, parallel-group study (2019)
Journal Article
Smith, J. A., McGarvey, L., Morice, A. H., Birring, S. S., Wedzicha, J. A., Notari, M., …Jarreta, D. (2019). The effect of aclidinium on symptoms including cough in chronic obstructive pulmonary disease: A phase 4, double-blind, placebo-controlled, parallel-group study. American Journal of Respiratory and Critical Care Medicine, 200(5), 642-645. https://doi.org/10.1164/rccm.201901-0048LE

Inhaled corticosteroids and placebo treatment effects in adult patients with cough: A systematic review and meta-analysis (2019)
Journal Article
Lee, S. E., Lee, J., Kim, H. J., Lee, B., Cho, S., Price, D., …Song, W. (2019). Inhaled corticosteroids and placebo treatment effects in adult patients with cough: A systematic review and meta-analysis. Allergy Asthma and Immunology Research, 11(6), 856-870. https://doi.org/10.4168/aair.2019.11.6.856

Purpose: Inhaled corticosteroids (ICSs) are often considered an empirical therapy in the management of patients with cough. However, ICS responsiveness is difficult to interpret in daily clinical practice, as the improvements may include placebo effe... Read More about Inhaled corticosteroids and placebo treatment effects in adult patients with cough: A systematic review and meta-analysis.

The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study (2019)
Journal Article
Morice, A. H., Kitt, M. M., Ford, A. P., Tershakovec, A. M., Wu, W. C., Brindle, K., …Wright, C. (2019). The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study. European respiratory journal, 54(1), Article 1900439. https://doi.org/10.1183/13993003.00439-2019

We evaluated the effect of gefapixant on cough reflex sensitivity to evoked tussive challenge. In this phase 2, double-blind, two-period study, patients with chronic cough (CC) and healthy volunteers (HV) were randomised to single-dose gefapixant... Read More about The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study.

Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: A rct (2019)
Journal Article
Devereux, G., Cotton, S., Fielding, S., McMeekin, N., Barnes, P. J., Briggs, A., …Price, D. (2019). Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: A rct. Health Technology Assessment, 23(37), 1-145. https://doi.org/10.3310/hta23370

Background: Despite widespread use of therapies such as inhaled corticosteroids (ICSs), people with chronic obstructive pulmonary disease (COPD) continue to suffer, have reduced life expectancy and utilise considerable NHS resources. Laboratory inves... Read More about Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: A rct.

New understanding in the treatment of cough (NEUROCOUGH) ERS Clinical Research Collaboration: improving care and treatment for patients with cough (2019)
Journal Article
McGarvey, L., Dupont, L., Birring, S. S., Boyd, J., Chung, K. F., Dabrowska, M., …Van de Kerkhove, C. (2019). New understanding in the treatment of cough (NEUROCOUGH) ERS Clinical Research Collaboration: improving care and treatment for patients with cough. European respiratory journal, 53(5), Article 1900787. https://doi.org/10.1183/13993003.00787-2019

Chronic cough is a common and troublesome clinical problem and currently there are no effective treatments [1]. While individual specialist cough clinics have been set up in some European countries, there is no formal mechanism to develop common mana... Read More about New understanding in the treatment of cough (NEUROCOUGH) ERS Clinical Research Collaboration: improving care and treatment for patients with cough.

N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites (2019)
Journal Article
Chandrabalan, A., McPhillie, M. J., Morice, A. H., Boa, A. N., & Sadofsky, L. R. (2019). N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites. European Journal of Medicinal Chemistry, 170, 141-156. https://doi.org/10.1016/j.ejmech.2019.02.074

The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel, which detects noxious stimuli leading to pain, itch and cough. However, the mechanism(s) of channel modulation by many of the known, non-reactive modulators... Read More about N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.

Symptoms and exacerbations in asthma: an apparent paradox? (2019)
Journal Article
Morjaria, J. B., Rigby, A. S., & Morice, A. H. (2019). Symptoms and exacerbations in asthma: an apparent paradox?. Therapeutic Advances in Chronic Disease, 10, https://doi.org/10.1177/2040622319884387

© The Author(s), 2019. Background: There is a dearth of data on prospectively recorded symptoms in patients with uncontrolled asthma. Asthma symptoms and exacerbation rate are commonly thought to be associated. The aim of this study was to analyse as... Read More about Symptoms and exacerbations in asthma: an apparent paradox?.

Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria (2018)
Journal Article
Vance, J., Santos, A., Sadofsky, L., Morice, A., & Cervantes, J. (2019). Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria. Lung, 197(1), 89–94. https://doi.org/10.1007/s00408-018-0181-z

Purpose Diabetes mellitus (DBM) reduces immunological activity and increases susceptibility to various infections, including tuberculosis (TB). Human alveolar macrophage (hAM) functions are altered in DBM. Methods To mimic hyperglycemic conditions i... Read More about Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria.

Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients with COPD: A Randomized Clinical Trial (2018)
Journal Article
Devereux, G., Cotton, S., Fielding, S., McMeekin, N., Barnes, P. J., Briggs, A., …Price, D. (2018). Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients with COPD: A Randomized Clinical Trial. Journal of the American Medical Association, 320(15), 1548-1559. https://doi.org/10.1001/jama.2018.14432

© 2018 American Medical Association. All rights reserved. Importance: Chronic obstructive pulmonary disease (COPD) is a major global health issue and theophylline is used extensively. Preclinical investigations have demonstrated that low plasma conce... Read More about Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients with COPD: A Randomized Clinical Trial.

Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis (2018)
Journal Article
Aliyu, S. A., Avery, G., Cawthorne, C., Archibald, S. J., Kadir, T., Willaime, J. M., …Crooks, M. G. (2018). Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis. European respiratory journal, 52(5), 1801138. https://doi.org/10.1183/13993003.01138-2018

Positron Emission Tomography (PET) scanning in idiopathic pulmonary fibrosis (IPF) has revealed increased [18F]-fluorodeoxyglucose ([18F]-FDG) uptake in areas of the lungs that appear normal on high resolution computed tomography (HRCT). We hypothesi... Read More about Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis.

Acute and chronic cough (2018)
Book Chapter
Morice, A. H., & Fowles, H. (2018). Acute and chronic cough. In S. Hart, & M. Greenstone (Eds.), Foundations of Respiratory Medicine (73-86). Cham: Springer. https://doi.org/10.1007/978-3-319-94127-1_5

Acute cough has a considerable economic impact within the UK because of lost work days. Chronic cough is one of the most common presentations to general respiratory clinics. Cough is often seen in tandem with a wide variety of respiratory conditions... Read More about Acute and chronic cough.

Anti reflux surgery (2018)
Book Chapter
Rai, Z., Morice, A. H., & Sedman, P. (2018). Anti reflux surgery. In A. H. Morice, & P. W. Dettmar (Eds.), Reflux Aspiration and Lung Disease (357-363). Cham: Springer. https://doi.org/10.1007/978-3-319-90525-9_28

Surgery may be necessary to control gross reflux disease, particularly when anatomical abnormalities underlie the pathophysiology. Treatment is generally less successful when directed at isolated airway reflux and aspiration since the refluxate consi... Read More about Anti reflux surgery.

XII AIST 2018 Conference: "the thousand faces of cough: Clinical and therapeutic updates" (2018)
Journal Article
Zanasi, A., Morselli-Labate, A. M., Mazzolini, M., Mastroroberto, M., Dal Negro, R. W., Poliacek, I., …Tursi, F. (2018). XII AIST 2018 Conference: "the thousand faces of cough: Clinical and therapeutic updates". Multidisciplinary Respiratory Medicine, 13(1), Article 17. https://doi.org/10.1186/s40248-018-0130-y

© 2018 The Author(s). This paper summarizes the presentations submitted for publication of the 12th AIST National Congress (Associazione Italiana Studio Tosse/Italian Association for Cough Study) entitled "The thousand facets of cough. A clinical and... Read More about XII AIST 2018 Conference: "the thousand faces of cough: Clinical and therapeutic updates".

The role of high resolution oesophageal manometry in occult respiratory symptoms (2018)
Journal Article
Burke, J. M., Jackson, W., & Morice, A. H. (2018). The role of high resolution oesophageal manometry in occult respiratory symptoms. Respiratory medicine, 138, 47-49. https://doi.org/10.1016/j.rmed.2018.03.027

Purpose: Cough Hypersensitivity Syndrome is the urge to cough following minimal stimulation, but its mechanism and method of provocation remain unexplained. 121 patients (44 males, 77 females; age range 18–81 years) were evaluated. Procedures: High r... Read More about The role of high resolution oesophageal manometry in occult respiratory symptoms.