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All Outputs (167)

Worldwide survey of chronic cough: A manifestation of enhanced somatosensory response (2014)
Journal Article
Morice, A. H., Jakes, A. D., Faruqi, S., Birring, S. S., Mcgarvey, L., Canning, B., …Dicpinigaitis, P. (2014). Worldwide survey of chronic cough: A manifestation of enhanced somatosensory response. European respiratory journal, 44(5), 1149-1155. https://doi.org/10.1183/09031936.00217813

© ERS 2014. Reports from individual centres suggest a preponderance of females with chronic cough. Females also have heightened cough reflex sensitivity. Here we have reviewed the age and sex of unselected referrals to 11 cough clinics. To investigat... Read More about Worldwide survey of chronic cough: A manifestation of enhanced somatosensory response.

Is opiate action in cough due to sedation? (2014)
Journal Article
Dickinson, R. S., Morjaria, J. B., Wright, C. E., & Morice, A. H. (2014). Is opiate action in cough due to sedation?. Therapeutic Advances in Chronic Disease, 5(5), 200-205. https://doi.org/10.1177/2040622314543220

Opiates have been used for cough suppression for centuries. It is unclear whether this antitussive action is due to their known sedative effects. We aimed to assess correlation between cough suppression and opiate usage. Methods: We performed a post... Read More about Is opiate action in cough due to sedation?.

A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers (2014)
Journal Article
Faruqi, S., Wright, C., Thompson, R., & Morice, A. H. (2014). A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers. British Journal of Clinical Pharmacology, 78(6), 1272-1280. https://doi.org/10.1111/bcp.12458

AIMS The examination of cough reflex sensitivity through inhalational challenge can be utilized to demonstrate pharmacological end points. Here we compare the effect of butamirate, dextromethorphan and placebo on capsaicin-induced cough in healthy vo... Read More about A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers.

Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor (2014)
Journal Article
Morgan, K., Sadofsky, L. R., Crow, C., & Morice, A. H. (2014). Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor. Bioscience Reports, 34(4), 469-478. https://doi.org/10.1042/BSR20140061

TRPM8 (transient receptor potential M8) and TRPA1 (transient receptor potential A1) are cold-temperature-sensitive nociceptors expressed in sensory neurons but their behaviour in neuronal cells is poorly understood. Therefore DNA expression construct... Read More about Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor.

Unique responses are observed in transient receptor potential ankyrin 1 and vanilloid 1 (TRPA1 and TRPV1) co-expressing cells (2014)
Journal Article
Sadofsky, L. R., Sreekrishna, K. T., Lin, Y., Schinaman, R., Gorka, K., Mantri, Y., …Morice, A. H. (2014). Unique responses are observed in transient receptor potential ankyrin 1 and vanilloid 1 (TRPA1 and TRPV1) co-expressing cells. Cells, 3(2), 616-626. https://doi.org/10.3390/cells3020616

Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1 and TRPV1 are often co-expressed in neurons and TRPA1V1 hetero-tetramer formation is noted in... Read More about Unique responses are observed in transient receptor potential ankyrin 1 and vanilloid 1 (TRPA1 and TRPV1) co-expressing cells.

On the definition of chronic cough and current treatment pathways: An international qualitative study (2014)
Journal Article
Faruqi, S., Murdoch, R. D., Allum, F., & Morice, A. H. (2014). On the definition of chronic cough and current treatment pathways: An international qualitative study. Cough, 10(1), Article 5. https://doi.org/10.1186/1745-9974-10-5

Background: The pathogenesis of chronic cough is not well understood and treatment options are limited. In this study we sought to explore the current understanding and management of chronic cough across an international group of specialists.Methods:... Read More about On the definition of chronic cough and current treatment pathways: An international qualitative study.

Antitussive drugs-past, present, and future (2014)
Journal Article
Dicpinigaitis, P. V., Morice, A. H., Birring, S. S., McGarvey, L., Smith, J. A., Canning, B. J., & Page, C. P. (2014). Antitussive drugs-past, present, and future. Pharmacological Reviews, 66(2), 468-512. https://doi.org/10.1124/pr.111.005116

Cough remains a serious unmet clinical problem, both as a symptom of a range of other conditions such as asthma, chronic obstructive pulmonary disease, gastroesophageal reflux, and as a problem in its own right in patients with chronic cough of unkno... Read More about Antitussive drugs-past, present, and future.

The effect of deep hypothermia on the human pulmonary circulation (2014)
Journal Article
Ariyaratnam, P., Loubani, M., Cale, A. R., Chaudhry, M., Cowen, M. E., Jarvis, M. A., …Morice, A. H. (2014). The effect of deep hypothermia on the human pulmonary circulation. Journal of Thermal Biology, 40(1), 20-24. https://doi.org/10.1016/j.jtherbio.2014.01.001

Objective: Acute rises in pulmonary artery pressures following complex cardiac surgery are associated with high morbidity and mortality. We hypothesised that periods of deep hypothermia predispose to elevated pulmonary pressures upon rewarming. We in... Read More about The effect of deep hypothermia on the human pulmonary circulation.

Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. (2014)
Journal Article
Fahim, A., Crooks, M. G., Morice, A. H., & Hart, S. P. (2014). Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. Lung, 192(2), 277-284. https://doi.org/10.1007/s00408-013-9546-5

Purpose Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and its prognosis is poor. Epidemiological evidence suggests an association of IPF with vascular disease and thrombotic tendency, which may be related to... Read More about Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis..

Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire (2013)
Journal Article
Smith, J. E., Morjaria, J. B., & Morice, A. H. (2013). Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire. Cough, 9(1), Article 27. https://doi.org/10.1186/1745-9974-9-27

Background: Chronic cough is a common and distressing symptom. Gastro-oesophageal reflux is a common cause of chronic cough however the symptom complex in cough is not confined to classic peptic symptoms. Dyspeptic symptoms have previously been shown... Read More about Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire.

Cough in the Elderly Population: Relationships with Multiple Comorbidity (2013)
Journal Article
Song, W. J., Morice, A. H., Kim, M. H., Lee, S. E., Jo, E. J., Lee, S. M., …Chang, Y. S. (2013). Cough in the Elderly Population: Relationships with Multiple Comorbidity. PLoS ONE, 8(10), Article e78081. https://doi.org/10.1371/journal.pone.0078081

Background:The epidemiology of cough in the elderly population has not been studied comprehensively. The present study aimed to investigate the epidemiology of cough in a community elderly population, particularly in relation with their comorbidity.M... Read More about Cough in the Elderly Population: Relationships with Multiple Comorbidity.

Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension? (2013)
Journal Article
Ariyaratnam, P., Loubani, M., & Morice, A. H. (2013). Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension?. Microvascular Research, 90, 135-137. https://doi.org/10.1016/j.mvr.2013.09.002

Introduction: Acute rises in pulmonary artery pressures are associated with a significant mortality and morbidity due to the significant strain on the right ventricle. Although hydrogen sulphide (H2S) has been studied for its potential role in the sy... Read More about Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension?.

Hypoxic pulmonary vasoconstriction in humans (2013)
Journal Article
Ariyaratnam, P., Loubani, M., & Morice, A. H. (2013). Hypoxic pulmonary vasoconstriction in humans. Biomed research international, 2013, Article 623684. https://doi.org/10.1155/2013/623684

Hypoxic pulmonary vasoconstriction is the elegant theory put forward more than six decades ago to explain regional variations in perfusion within the lung in certain animal species in response to localised restrictions in oxygenation. Although consid... Read More about Hypoxic pulmonary vasoconstriction in humans.

Airway reflux as a cause of respiratory disease (2013)
Journal Article
Morice, A. H. (2013). Airway reflux as a cause of respiratory disease. Breathe, 9(4), 257-266. https://doi.org/10.1183/20734735.000513

Reflux is the cause of much respiratory disease. More commonly still, it is the unrecognised agent provoking the symptoms of respiratory disease. That the reflux entering the airways from the gastrointestinal tract is central to the diagnosis, therap... Read More about Airway reflux as a cause of respiratory disease.

Symptoms of airway reflux predict exacerbations and quality of life in bronchiectasis (2013)
Journal Article
Mandal, P., Morice, A. H., Chalmers, J. D., & Hill, A. T. (2013). Symptoms of airway reflux predict exacerbations and quality of life in bronchiectasis. Respiratory medicine, 107(7), 1008-1013. https://doi.org/10.1016/j.rmed.2013.04.006

Aim We have explored the association of the upper airway symptoms related to cough with exacerbation frequency, sputum microbiology and inflammatory markers in patients with non cystic fibrosis bronchiectasis. Methods Patients with bronchiectasis com... Read More about Symptoms of airway reflux predict exacerbations and quality of life in bronchiectasis.

Chronic cough hypersensitivity syndrome (2013)
Journal Article
Morice, A. H. (2013). Chronic cough hypersensitivity syndrome. Cough, 9(1), Article 14. https://doi.org/10.1186/1745-9974-9-14

Chronic cough has been suggested to be due to three conditions, asthma, post nasal drip, and reflux disease. A different paradigm has evolved in which cough is viewed as the primary condition characterised by afferent neuronal hypersensitivity and di... Read More about Chronic cough hypersensitivity syndrome.

Management of patients with chronic cough using a clinical protocol: A prospective observational study (2013)
Journal Article
Ojoo, O. C., Everett, C. F., Mulrennan, S. A., Faruqi, S., Kastelik, J. A., & Morice, A. H. (2013). Management of patients with chronic cough using a clinical protocol: A prospective observational study. Cough, 9(1), Article 2. https://doi.org/10.1186/1745-9974-9-2

Background and aims: Chronic cough is a common symptom the aetiology of which can be challenging to diagnose. Diagnostic protocols for chronic cough have required the use of specialist investigations which are not always easily available. We wanted t... Read More about Management of patients with chronic cough using a clinical protocol: A prospective observational study.

Novel antitussive strategies (2012)
Journal Article
Morjaria, J. B., Dickinson, R. S., & Morice, A. H. (2013). Novel antitussive strategies. Drug Discovery Today, 18(7-8), 380-388. https://doi.org/10.1016/j.drudis.2012.11.004

Acute and chronic cough represent one of the most common symptoms of medical importance but effective pharmacotherapy is, to all intents and purposes, absent. Numerous initiatives targeting the recently discovered tussive pathways are in progress. He... Read More about Novel antitussive strategies.

Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis (2012)
Journal Article
Fahim, A., Crooks, M., Wilmot, R., Campbell, A. P., Morice, A., & Hart, S. (2012). Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis. Respirology : official journal of the Asian Pacific Society of Respirology, 17(8), 1247-1252. https://doi.org/10.1111/j.1440-1843.2012.02231.x

Background and objective: Idiopathic pulmonary fibrosis (IPF) is the commonest idiopathic interstitial pneumonia and carries a poor prognosis. Epidemiological evidence suggests that patients with IPF have an increased risk of developing lung cancer.... Read More about Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis.