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Chronic Cough in Musculoskeletal disorders: Using high resolution oesophageal manometry in search of an Aetiology (2012)
Journal Article
Pathmanathan, S., Morjaria, J. B., Morice, A. H., & Jackson, W. (2012). Chronic Cough in Musculoskeletal disorders: Using high resolution oesophageal manometry in search of an Aetiology. Cough, 8(1), Article 6. https://doi.org/10.1186/1745-9974-8-6

Chronic cough is a common symptom carrying significant morbidity which can occur as a result of oesophageal dysmotility. Here we report 2 patients with musculoskeletal disease presenting with chronic cough to our tertiary cough clinic. Prior to refer... Read More about Chronic Cough in Musculoskeletal disorders: Using high resolution oesophageal manometry in search of an Aetiology.

Fundoplication in chronic intractable cough (2012)
Journal Article
Faruqi, S., Sedman, P., Jackson, W., Molyneux, I., & Morice, A. H. (2012). Fundoplication in chronic intractable cough. Cough, 8(1), Article 3. https://doi.org/10.1186/1745-9974-8-3

Background: Airway reflux is a common cause of chronic cough and this is often refractory to medical therapy. Surgery in the form of Nissen fundoplication has been highly successful in the treatment of the classic reflux symptoms of heartburn and dys... Read More about Fundoplication in chronic intractable cough.

Comparison of the effect of high-dose inhaled budesonide and fluticasone on adrenal function in patients with severe chronic obstructive pulmonary disease (2012)
Journal Article
Fahim, A., Faruqi, S., Wright, C. E., Kastelik, J. A., & Morice, A. H. (2012). Comparison of the effect of high-dose inhaled budesonide and fluticasone on adrenal function in patients with severe chronic obstructive pulmonary disease. Annals of Thoracic Medicine, 7(3), 140-144. https://doi.org/10.4103/1817-1737.98846

Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of respiratory-related morbidity and mortality. Inhaled steroids are frequently used in patients with moderate to severe disease and may lead to adrenal suppression. Object... Read More about Comparison of the effect of high-dose inhaled budesonide and fluticasone on adrenal function in patients with severe chronic obstructive pulmonary disease.

Cognitive behavioural intervention for adults with anxiety complications of asthma: Prospective randomised trial (2012)
Journal Article
Parry, G. D., Cooper, C. L., Moore, J. M., Yadegarfar, G., Campbell, M. J., Esmonde, L., …Hutchcroft, B. J. (2012). Cognitive behavioural intervention for adults with anxiety complications of asthma: Prospective randomised trial. Respiratory medicine, 106(6), 802-810. https://doi.org/10.1016/j.rmed.2012.02.006

Background: High levels of asthma-related fear and panic exacerbate asthma symptoms and complicate the management of asthma. Asthma-specific fear may be reduced by a cognitive behavioural intervention. We aimed to test if there is a reduction in asth... Read More about Cognitive behavioural intervention for adults with anxiety complications of asthma: Prospective randomised trial.

Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts (2012)
Journal Article
Sadofsky, L. R., Ramachandran, R., Crow, C., Cowen, M., Compton, S. J., & Morice, A. H. (2012). Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts. Experimental Lung Research, 38(2), 75-81. https://doi.org/10.3109/01902148.2011.644027

Lung fibroblasts are involved in interstitial lung disease, chronic asthma, and chronic obstructive pulmonary disease (COPD). The expanded fibroblast population in airway disease leads to airway remodeling and contributes to the inflammatory process... Read More about Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts.

Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate (2011)
Journal Article
Morice, A. H., McGarvey, L. P., & Dicpinigaitis, P. V. (2012). Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate. Lung, 190(1), 3-9. https://doi.org/10.1007/s00408-011-9351-y

The major etiologies of chronic cough are generally accepted to consist of upper airway cough syndrome (formerly postnasal drip syndrome), eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), and gastroesophageal reflux di... Read More about Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate.

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study (2011)
Journal Article
Faruqi, S., Molyneux, I. D., Fathi, H., Wright, C., Thompson, R., & Morice, A. H. (2011). Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study. Respirology : official journal of the Asian Pacific Society of Respirology, 16(7), 1150-1156. https://doi.org/10.1111/j.1440-1843.2011.02014.x

Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication. Esomeprazole is a proton pump inhibitor licensed for the lon... Read More about Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study.

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis (2011)
Journal Article
Botham, A., Guo, X., Xiao, Y. P., Morice, A. H., Compton, S., & Sadofsky, L. R. (2011). Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Biochemical Journal, 438(2), 359-367. https://doi.org/10.1042/BJ20101958

hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological studies have found that activation o... Read More about Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis.

Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough (2011)
Journal Article
Pacheco, A., Faro, V., Cobeta, I., Royuela, A., Molyneux, I., & Morice, A. H. (2011). Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough. Respirology : official journal of the Asian Pacific Society of Respirology, 16(6), 994-999. https://doi.org/10.1111/j.1440-1843.2011.02010.x

Background and objective: Patients with eosinophilic airway inflammation (EAI) often show a therapeutic response to corticosteroids. Non-invasive methods of diagnosing EAI are potentially useful in guiding therapy, particularly in conditions such as... Read More about Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough.

Serum LDH in chronic cough: A potential marker of airway inflammation (2011)
Journal Article
Faruqi, S., Wilmot, R., Wright, C., & Morice, A. H. (2012). Serum LDH in chronic cough: A potential marker of airway inflammation. Clinical Respiratory Journal, 6(2), 81-87. https://doi.org/10.1111/j.1752-699X.2011.00250.x

Introduction and Objectives: Lactate dehydrogenase (LDH) is found in almost all tissues of the body and five different isoenzymes are known (LDH-1 to LDH-5). LDH can be elevated in many pathological conditions. We have observed serum LDH to be increa... Read More about Serum LDH in chronic cough: A potential marker of airway inflammation.

N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin (2011)
Journal Article
Xiao, Y. P., Morice, A. H., Compton, S. J., & Sadofsky, L. (2011). N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin. Journal of Biological Chemistry, 286(26), 22991-23002. https://doi.org/10.1074/jbc.M110.204271

Proteinase-activated receptor 1 (PAR1) induces activation of platelet and vascular cells after proteolytic cleavage of its extracellular N terminus by thrombin. In pathological situations, other proteinases may be generated in the circulation and mig... Read More about N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin.

Cough hypersensitivity syndrome: A distinct clinical entity (2010)
Journal Article
Morice, A. H., Faruqi, S., Wright, C. E., Thompson, R., & Bland, J. M. (2011). Cough hypersensitivity syndrome: A distinct clinical entity. Lung, 189(1), 73-79. https://doi.org/10.1007/s00408-010-9272-1

We postulate that most patients with chronic cough have a single discrete clinical entity: Cough Hypersensitivity Syndrome. We constructed a questionnaire that elicits the major components of the syndrome. Here we describe the validation of this ques... Read More about Cough hypersensitivity syndrome: A distinct clinical entity.

TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids (2010)
Journal Article
Sadofsky, L. R., Boa, A. N., Maher, S. A., Birrell, M. A., Belvisi, M. G., & Morice, A. H. (2011). TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids. Pharmacological research : the official journal of the Italian Pharmacological Society, 63(1), 30-36. https://doi.org/10.1016/j.phrs.2010.11.004

The nociceptor TRPA1 is thought to be activated through covalent modification of specific cysteine residues on the N terminal of the channel. The precise mechanism of covalent modification with unsaturated carbonyl-containing compounds is unclear, th... Read More about TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids.