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mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells (2017)
Journal Article
Ardestani, A., Lupse, B., Kido, Y., Leibowitz, G., & Maedler, K. (2018). mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells. Cell Metabolism, 27(2), 314-331. https://doi.org/10.1016/j.cmet.2017.11.004

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic and nutrient cues that integrates environmental inputs into downstream signaling pathways to control cellular metabolism, growth, and survival. While numerous... Read More about mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells.

The Hippo signaling pathway in pancreatic β-cells: Functions and regulations (2017)
Journal Article
Ardestani, A., & Maedler, K. (2018). The Hippo signaling pathway in pancreatic β-cells: Functions and regulations. Endocrine Reviews, 39(1), 21-35. https://doi.org/10.1210/er.2017-00167

Hippo signaling is an evolutionarily conserved pathway that critically regulates development and homeostasis of various tissues in response to a wide range of extracellular and intracellular signals. As an emerging important player in many diseases,... Read More about The Hippo signaling pathway in pancreatic β-cells: Functions and regulations.

mTORC in β cells: More Than Only Recognizing Comestibles (2017)
Journal Article
Maedler, K., & Ardestani, A. (2017). mTORC in β cells: More Than Only Recognizing Comestibles. Journal of Cell Biology, 216(7), 1883-1885. https://doi.org/10.1083/jcb.201704179

The pathways regulating pancreatic β cell survival in diabetes are poorly understood. Here, Chau et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701085) demonstrate that mTOR regulates the apoptotic machinery through binding to the ChREBP-... Read More about mTORC in β cells: More Than Only Recognizing Comestibles.